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10.1016/j.neuron.2016.03.011 http://scihub22266oqcxt.onion/10.1016/j.neuron.2016.03.011 C4840048!4840048!27068791     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuron 2016 ; 90 (2): 278-91 Nephropedia Template TP {{tp|p=27068791|t=2016. Glycolytic enzymes localize to synapses under energy stress to support synaptic function |pdf=|usr=}}{{27068791}} gab.com Text Glycolytic enzymes localize to synapses under energy stress to support synaptic function JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=27068791 #FOAvip Changes in neuronal activity create local and transient changes in energy demands at synapses. Here we discover a metabolic compartment that forms in vivo near synapses to meet local energy demands and support synaptic function in Caenorhabditis elegans neurons. Under conditions of energy stress, glycolytic enzymes redistribute from a diffuse localization in the cytoplasm to a punctate localization adjacent to synapses. Glycolytic enzymes colocalize, suggesting the ad hoc formation of a glycolysis compartment, or a ?glycolytic metabolon?, that can maintain local levels of ATP. Local formation of the glycolytic metabolon is dependent on presynaptic scaffolding proteins, and disruption of the glycolytic metabolon blocks the synaptic vesicle cycle, impairs synaptic recovery, and affects locomotion. Our studies indicate that under energy stress conditions, energy demands in C. elegans synapses are met locally through the assembly of a glycolytic metabolon to sustain synaptic function and behavior. Twit Text FOAVip Glycolytic enzymes localize to synapses under energy stress to support synaptic function ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=27068791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27068791 #FOAvip English Wikipedia <ref>{{Cite pmid|27068791}}</ref> Glycolytic enzymes localize to synapses under energy stress to support synaptic function #MMPMID27068791 Jang S; Nelson JC; Bend EG; Rodríguez-Laureano L; Tueros FG; Cartagenova L; Underwood K; Jorgensen EM; Colón-Ramos DA Neuron 2016[Apr]; 90 (2): 278-91 PMID27068791show ga Changes in neuronal activity create local and transient changes in energy demands at synapses. Here we discover a metabolic compartment that forms in vivo near synapses to meet local energy demands and support synaptic function in Caenorhabditis elegans neurons. Under conditions of energy stress, glycolytic enzymes redistribute from a diffuse localization in the cytoplasm to a punctate localization adjacent to synapses. Glycolytic enzymes colocalize, suggesting the ad hoc formation of a glycolysis compartment, or a ?glycolytic metabolon?, that can maintain local levels of ATP. Local formation of the glycolytic metabolon is dependent on presynaptic scaffolding proteins, and disruption of the glycolytic metabolon blocks the synaptic vesicle cycle, impairs synaptic recovery, and affects locomotion. Our studies indicate that under energy stress conditions, energy demands in C. elegans synapses are met locally through the assembly of a glycolytic metabolon to sustain synaptic function and behavior. äGlycolytic enzymes localize to synapses under energy stress to support(epmc).pdf DeepDyve Pubget Overpricing