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2016 ; 95
(11
): e3082
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Chemokine-Like Factor 1 (CKLF-1) is Overexpressed in Keloid Patients: A Potential
Indicating Factor for Keloid-Predisposed Individuals
#MMPMID26986142
Zhang M
; Xu Y
; Liu Y
; Cheng Y
; Zhao P
; Liu H
; Wang Y
; Ma X
Medicine (Baltimore)
2016[Mar]; 95
(11
): e3082
PMID26986142
show ga
Chemokine-like factor 1 (CKLF-1) is a novel cytokine which have a crucial role in
immune and inflammatory responses. In this study, the expression level of CKLF-1
was measured to assess the difference between keloid patients and people without
keloid. Fifty samples were taken from 30 patients: 10 keloid patients; 10 scar
patients; and 10 patients without obvious scarring. Patients were randomly
selected from the hospitalized patients of Peking Union Medical College Hospital
from September 2013 to July 2015. Five groups of samples were established: keloid
samples from keloid patients (K); normal skin samples from keloid patients (KS);
scar samples from scar patients (C); normal skin samples from scar patients (CS);
and normal skin samples from patients without obvious scarring (S). Hematoxylin
and eosin (H&E) staining was used to observe morphological changes. CKLF-1, IL-6,
IL-8, IL-18, and TGF-? were detected by immunohistochemical and western blot
technology. The expression of CKLF-1's mRNA was also measured by the real-time
quantitative polymerase chain reaction (RT-qPCR). Compared to the K group, the
other 4 groups presented significantly less inflammatory infiltration and lower
expression levels of CKLF-1, IL-6, IL-8, IL-18, and TGF-?. Among the 3 normal
skin groups, the expression level of CKLF-1 was significantly higher in the KS
group than in the CS or S group. The mRNA expression was also obvious in the K
and KS groups. CKLF-1 and other inflammatory factors were overexpressed in the
samples from keloid patients, indicating that the formation of keloid may be
related to inflammation and that CKLF-1 may play an important role in this
process.
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