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10.1097/MD.0000000000003341 http://scihub22266oqcxt.onion/10.1097/MD.0000000000003341 C4839832!4839832 !27082588     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27082588 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Medicine+(Baltimore) 2016 ; 95 (15 ): e3341 Nephropedia Template TP {{tp|p=27082588 |t=2016. The Adverse Events of Oxycodone in Cancer-Related Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |pdf=|usr=}}{{27082588 }} gab.com Text The Adverse Events of Oxycodone in Cancer-Related Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27082588 #FOAvip The adverse events (AEs) of oxycodone in cancer-related pain were controversial, so we conducted a meta-analysis to determine it. PubMed, Embase, CBM, CNKI, WanFang database, The Cochrane library, Web of Science, and the reference of included studies were searched to recognize pertinent studies. Relative risk (RR) with 95% confidence intervals (CIs) for all AEs were all extracted. The fixed-effects model was used to calculate pooled RRs and 95% CIs. Power calculation was performed using macro embedded in SAS software after all syntheses were completed. We identified 11 eligible trials involving 1211 patients: 604 patients included in oxycodone group and 607 patients involved in control group. Our quantitative analysis included 8 AEs, and the pooled analyses indicated that oxycodone compared with other opioids in cancer-related pain were not significantly decreased RRs of all AEs (dizziness RR?=?0.94, 95% CI: 0.69-1.30, Z?=?0.35, P?=?0.72; nausea RR?=?0.88, 95% CI: 0.72-1.07, Z?=?1.26, P?=?0.21; vomiting RR?=?0.89, 95% CI: 0.70-1.15, Z?=?0.9, P?=?0.37; sleepiness RR?=?0.86, 95% CI: 0.38-1.36, Z?=?0.36, P?=?0.72; constipation RR?=?0.98, 95% CI: 0.81-1.19, Z?=?0.21, P?=?0.83; anorexia RR?=?0.97, 95% CI?=?0.58-1.62, Z?=?0.11, P?=?0.91; pruritus RR?=?0.76, 95% CI: 0.44-1.30, Z?=?1.01, P?=?0.31; dysuria RR?=?0.33, 95% CI: 0.07-1.62, Z?=?1.36, P?=?0.1)]. The subgroup analysis shown that Ox controlled-release (CR) had less sleepiness compared with MS-contin (Mc) CR (RR?=?0.47, 95% CI: 0.25-0.90, P?=?0.02). The power analysis suggests that all AEs have low statistical power. The present meta-analysis detected that no statistically significant difference were found among oxycodone and other opioids in all AEs, but Ox CR may had less sleepiness compared with Mc CR when subgroup analysis were conducted. Twit Text FOAVip The Adverse Events of Oxycodone in Cancer-Related Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27082588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27082588 #FOAvip English Wikipedia <ref>{{Cite pmid|27082588 }}</ref> The Adverse Events of Oxycodone in Cancer-Related Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials #MMPMID27082588 Ma H ; Liu Y ; Huang L ; Zeng XT ; Jin SH ; Yue GJ ; Tian X ; Zhou JG Medicine (Baltimore) 2016[Apr]; 95 (15 ): e3341 PMID27082588 show ga The adverse events (AEs) of oxycodone in cancer-related pain were controversial, so we conducted a meta-analysis to determine it. PubMed, Embase, CBM, CNKI, WanFang database, The Cochrane library, Web of Science, and the reference of included studies were searched to recognize pertinent studies. Relative risk (RR) with 95% confidence intervals (CIs) for all AEs were all extracted. The fixed-effects model was used to calculate pooled RRs and 95% CIs. Power calculation was performed using macro embedded in SAS software after all syntheses were completed. We identified 11 eligible trials involving 1211 patients: 604 patients included in oxycodone group and 607 patients involved in control group. Our quantitative analysis included 8 AEs, and the pooled analyses indicated that oxycodone compared with other opioids in cancer-related pain were not significantly decreased RRs of all AEs (dizziness RR?=?0.94, 95% CI: 0.69-1.30, Z?=?0.35, P?=?0.72; nausea RR?=?0.88, 95% CI: 0.72-1.07, Z?=?1.26, P?=?0.21; vomiting RR?=?0.89, 95% CI: 0.70-1.15, Z?=?0.9, P?=?0.37; sleepiness RR?=?0.86, 95% CI: 0.38-1.36, Z?=?0.36, P?=?0.72; constipation RR?=?0.98, 95% CI: 0.81-1.19, Z?=?0.21, P?=?0.83; anorexia RR?=?0.97, 95% CI?=?0.58-1.62, Z?=?0.11, P?=?0.91; pruritus RR?=?0.76, 95% CI: 0.44-1.30, Z?=?1.01, P?=?0.31; dysuria RR?=?0.33, 95% CI: 0.07-1.62, Z?=?1.36, P?=?0.1)]. The subgroup analysis shown that Ox controlled-release (CR) had less sleepiness compared with MS-contin (Mc) CR (RR?=?0.47, 95% CI: 0.25-0.90, P?=?0.02). The power analysis suggests that all AEs have low statistical power. The present meta-analysis detected that no statistically significant difference were found among oxycodone and other opioids in all AEs, but Ox CR may had less sleepiness compared with Mc CR when subgroup analysis were conducted. |Analgesics, Opioid/*adverse effects/therapeutic use [MESH] |Delayed-Action Preparations [MESH] |Humans [MESH] |Neoplasms/*complications [MESH] |Oxycodone/*adverse effects/therapeutic use [MESH] |Pain/*drug therapy/*etiology [MESH]The Adverse Events of Oxycodone in Cancer-Related Pain: A Systematic R(epmc).pdf DeepDyve Pubget Overpricing