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10.1097/MD.0000000000003033

http://scihub22266oqcxt.onion/10.1097/MD.0000000000003033
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suck abstract from ncbi


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pmid27082547
      Medicine+(Baltimore) 2016 ; 95 (15 ): e3033
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  • Histiocytoid Sweet Syndrome Is More Frequently Associated With Myelodysplastic Syndromes Than the Classical Neutrophilic Variant: A Comparative Series of 62 Patients #MMPMID27082547
  • Ghoufi L ; Ortonne N ; Ingen-Housz-Oro S ; Barhoumi W ; Begon E ; Haioun C ; Pautas C ; Beckerich F ; Robin C ; Wolkenstein P ; Cordonnier C ; Chosidow O ; Toma A
  • Medicine (Baltimore) 2016[Apr]; 95 (15 ): e3033 PMID27082547 show ga
  • Histiocytoid Sweet syndrome (H-SS) is a histological variant of Sweet syndrome (SS) differing from classical neutrophilic SS (N-SS) by a dermal infiltrate mainly composed of lymphocytes and histiocytoid myeloperoxidase-positive cells. We aimed to report a large series of H-SS and compare the frequency and type of hematological malignancies associated to H-SS and N-SS. We included 62 patients with a coding histopathologic diagnosis of SS prospectively registered between 2005 and 2014 in the database of our Department of Pathology. Overall, 22 (35.5%) and 40 (64.5%) patients had a histological diagnosis of H-SS and N-SS, respectively. Median age, sex ratio, and cutaneous lesions were similar in the 2 groups. The frequency of extra-cutaneous manifestations was similar (50% vs 37.5%, P?=?0.42). Recurrent forms were significantly more frequent in H-SS than in N-SS patients (21% vs 2.5%, P?=?0.01). A hematological malignancy was diagnosed in 22 patients, 12 (55.5%) with H-SS and 10 (25%) with N-SS (P?=?0.019). Hematological malignancy was of myeloid origin in 8/22 (36.3%) H-SS and 5/40 (12.5%) N-SS patients (P?=?0.02), and of lymphoid origin without myeloid component in 4/22 (18.1%) H-SS and 4/40 (10%) N-SS patients (P?=?0.35), respectively. One N-SS patient had a hematological malignancy of mixed (myeloid and lymphoid) phenotype. A myelodysplastic syndrome (MDS) was diagnosed in 7/22 (31.8%) H-SS and 1/40 (2.5%) N-SS patients (P?
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Age Factors [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Blood Cell Count [MESH]
  • |Female [MESH]
  • |Hematologic Neoplasms/epidemiology [MESH]
  • |Histiocytes/*pathology [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Myelodysplastic Syndromes/*epidemiology [MESH]
  • |Neutrophils/*pathology [MESH]
  • |Recurrence [MESH]
  • |Retrospective Studies [MESH]
  • |Sex Factors [MESH]
  • |Sweet Syndrome/classification/*epidemiology/*physiopathology [MESH]


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