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Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the
Mammalian Species and Cell Types
#MMPMID27101102
Momose F
; Seo N
; Akahori Y
; Sawada S
; Harada N
; Ogura T
; Akiyoshi K
; Shiku H
PLoS One
2016[]; 11
(4
): e0154134
PMID27101102
show ga
Exosome is an extracellular vesicle released from multivesicular endosomes and
contains micro (mi) RNAs and functional proteins derived from the donor cells.
Exosomal miRNAs act as an effector during communication with appropriate
recipient cells, this can aid in the utilization of the exosomes in a drug
delivery system for various disorders including malignancies. Differences in the
miRNA distribution pattern between exosomes and donor cells indicate the active
translocation of miRNAs into the exosome cargos in a miRNA sequence-dependent
manner, although the molecular mechanism is little known. In this study, we
statistically analyzed the miRNA microarray data and revealed that the guanine
(G)-rich sequence is a dominant feature of exosome-dominant miRNAs, across the
mammalian species-specificity and the cell types. Our results provide important
information regarding the potential use of exosome cargos to develop miRNA-based
drugs for the treatment of human diseases.
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