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Augmentation of Autoantibodies by Helicobacter pylori in Parkinson s Disease
Patients May Be Linked to Greater Severity
#MMPMID27100827
Suwarnalata G
; Tan AH
; Isa H
; Gudimella R
; Anwar A
; Loke MF
; Mahadeva S
; Lim SY
; Vadivelu J
PLoS One
2016[]; 11
(4
): e0153725
PMID27100827
show ga
Parkinson's disease (PD) is the second most common chronic and progressive
neurodegenerative disorder. Its etiology remains elusive and at present only
symptomatic treatments exists. Helicobacter pylori chronically colonizes the
gastric mucosa of more than half of the global human population. Interestingly,
H. pylori positivity has been found to be associated with greater of PD motor
severity. In order to investigate the underlying cause of this association, the
Sengenics Immunome protein array, which enables simultaneous screening for
autoantibodies against 1636 human proteins, was used to screen the serum of 30 H.
pylori-seropositive PD patients (case) and 30 age- and gender-matched H.
pylori-seronegative PD patients (control) in this study. In total, 13 significant
autoantibodies were identified and ranked, with 8 up-regulated and 5
down-regulated in the case group. Among autoantibodies found to be elevated in H.
pylori-seropositive PD were included antibodies that recognize Nuclear factor I
subtype A (NFIA), Platelet-derived growth factor B (PDGFB) and Eukaryotic
translation initiation factor 4A3 (eIFA3). The presence of elevated
autoantibodies against proteins essential for normal neurological functions
suggest that immunomodulatory properties of H. pylori may explain the association
between H. pylori positivity and greater PD motor severity.
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