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Diplomatic Assistance: Can Helminth-Modulated Macrophages Act as Treatment for
Inflammatory Disease?
#MMPMID27101372
Steinfelder S
; O'Regan NL
; Hartmann S
PLoS Pathog
2016[Apr]; 12
(4
): e1005480
PMID27101372
show ga
Helminths have evolved numerous pathways to prevent their expulsion or
elimination from the host to ensure long-term survival. During infection, they
target numerous host cells, including macrophages, to induce an alternatively
activated phenotype, which aids elimination of infection, tissue repair, and
wound healing. Multiple animal-based studies have demonstrated a significant
reduction or complete reversal of disease by helminth infection, treatment with
helminth products, or helminth-modulated macrophages in models of allergy,
autoimmunity, and sepsis. Experimental studies of macrophage and helminth
therapies are being translated into clinical benefits for patients undergoing
transplantation and those with multiple sclerosis. Thus, helminths or
helminth-modulated macrophages present great possibilities as therapeutic
applications for inflammatory diseases in humans. Macrophage-based helminth
therapies and the underlying mechanisms of their therapeutic or curative effects
represent an under-researched area with the potential to open new avenues of
treatment. This review explores the application of helminth-modulated macrophages
as a new therapy for inflammatory diseases.
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