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10.1152/ajpregu.00135.2015

http://scihub22266oqcxt.onion/10.1152/ajpregu.00135.2015
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C4839474!4839474!26136532
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suck abstract from ncbi


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pmid26136532      Am+J+Physiol+Regul+Integr+Comp+Physiol 2015 ; 309 (9): R1068-70
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  • Renal mineralocorticoid receptor and electrolyte homeostasis #MMPMID26136532
  • Terker AS; Ellison DH
  • Am J Physiol Regul Integr Comp Physiol 2015[Nov]; 309 (9): R1068-70 PMID26136532show ga
  • The renal mineralocorticoid receptor (MR) is a steroid hormone receptor essential for maintaining electrolyte homeostasis. Its role in mediating effects of aldosterone was likely vital in enabling the evolution of terrestrial life. Dysregulated aldosterone-MR signaling has been identified as the cause of multiple clinical diseases, suggesting the physiological importance of the MR. While the physiology of this pathway has been studied for over 60 years, only more recently have genetic mouse models been available to dissect its function in vivo. This review will focus on recent advances in our knowledge of MR function with an emphasis on these models.
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