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10.1007/s12105-016-0706-9 http://scihub22266oqcxt.onion/10.1007/s12105-016-0706-9 C4838974!4838974!26971503     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Head+Neck+Pathol 2016 ; 10 (2): 119-24 Nephropedia Template TP {{tp|p=26971503|t=2016. Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome) |pdf=|usr=}}{{26971503}} gab.com Text Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome) JO: Head Neck Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26971503 #FOAvip Nevoid basal cell carcinoma syndrome, or basal cell nevus syndrome (Gorlin syndrome), is a rare autosomal dominantly inherited disorder that is characterized by development of basal cell carcinomas from a young age. Other distinguishing clinical features are seen in a majority of patients, and include keratocystic odontogenic tumors (formerly odontogenic keratocysts) as well as dyskeratotic palmar and plantar pitting. A range of skeletal and other developmental abnormalities are also often seen. The disorder is caused by defects in hedgehog signaling which result in constitutive pathway activity and tumor cell proliferation. As sporadic basal cell carcinomas also commonly harbor hedgehog pathway aberrations, therapeutic agents targeting key signaling constituents have been developed and tested against advanced sporadically occurring tumors or syndromic disease, leading in 2013 to FDA approval of the first hedgehog pathway-targeted small molecule, vismodegib. The elucidation of the molecular pathogenesis of nevoid basal cell carcinoma syndrome has resulted in further understanding of the most common human malignancy. Twit Text FOAVip Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome) ????Head Neck Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26971503 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26971503 #FOAvip English Wikipedia <ref>{{Cite pmid|26971503}}</ref> Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome) #MMPMID26971503 Bresler SC; Padwa BL; Granter SR Head Neck Pathol 2016[Jun]; 10 (2): 119-24 PMID26971503show ga Nevoid basal cell carcinoma syndrome, or basal cell nevus syndrome (Gorlin syndrome), is a rare autosomal dominantly inherited disorder that is characterized by development of basal cell carcinomas from a young age. Other distinguishing clinical features are seen in a majority of patients, and include keratocystic odontogenic tumors (formerly odontogenic keratocysts) as well as dyskeratotic palmar and plantar pitting. A range of skeletal and other developmental abnormalities are also often seen. The disorder is caused by defects in hedgehog signaling which result in constitutive pathway activity and tumor cell proliferation. As sporadic basal cell carcinomas also commonly harbor hedgehog pathway aberrations, therapeutic agents targeting key signaling constituents have been developed and tested against advanced sporadically occurring tumors or syndromic disease, leading in 2013 to FDA approval of the first hedgehog pathway-targeted small molecule, vismodegib. The elucidation of the molecular pathogenesis of nevoid basal cell carcinoma syndrome has resulted in further understanding of the most common human malignancy. äNevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome) (epmc).pdf DeepDyve Pubget Overpricing