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10.1038/ncomms11361 http://scihub22266oqcxt.onion/10.1038/ncomms11361 C4838891!4838891!27093631     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27093631.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27093631|t=2016. NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction |pdf=|usr=}}{{27093631}} gab.com Text NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27093631 #FOAvip Indian Echis carinatus bite causes sustained tissue destruction at the bite site. Neutrophils, the major leukocytes in the early defence process, accumulate at the bite site. Here we show that E. carinatus venom induces neutrophil extracellular trap (NET) formation. The NETs block the blood vessels and entrap the venom toxins at the injection site, promoting tissue destruction. The stability of NETs is attributed to the lack of NETs-degrading DNase activity in E. carinatus venom. In a mouse tail model, mice co-injected with venom and DNase 1, and neutropenic mice injected with the venom, do not develop NETs, venom accumulation and tissue destruction at the injected site. Strikingly, venom-induced mice tail tissue destruction is also prevented by the subsequent injection of DNase 1. Thus, our study suggests that DNase 1 treatment may have a therapeutic potential for preventing the tissue destruction caused by snake venom. Twit Text FOAVip NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27093631 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27093631 #FOAvip English Wikipedia <ref>{{Cite pmid|27093631}}</ref> NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction #MMPMID27093631 Katkar GD; Sundaram MS; NaveenKumar SK; Swethakumar B; Sharma RD; Paul M; Vishalakshi GJ; Devaraja S; Girish KS; Kemparaju K Nat Commun 2016[]; 7 (ä): ä PMID27093631show ga Indian Echis carinatus bite causes sustained tissue destruction at the bite site. Neutrophils, the major leukocytes in the early defence process, accumulate at the bite site. Here we show that E. carinatus venom induces neutrophil extracellular trap (NET) formation. The NETs block the blood vessels and entrap the venom toxins at the injection site, promoting tissue destruction. The stability of NETs is attributed to the lack of NETs-degrading DNase activity in E. carinatus venom. In a mouse tail model, mice co-injected with venom and DNase 1, and neutropenic mice injected with the venom, do not develop NETs, venom accumulation and tissue destruction at the injected site. Strikingly, venom-induced mice tail tissue destruction is also prevented by the subsequent injection of DNase 1. Thus, our study suggests that DNase 1 treatment may have a therapeutic potential for preventing the tissue destruction caused by snake venom. äNETosis and lack of DNase activity are key factors in Echis carinatus (epmc).pdf DeepDyve Pubget Overpricing