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10.1016/j.immuni.2016.02.005 http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.02.005 C4838559!4838559!27037190     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2016 ; 44 (4): 807-20 Nephropedia Template TP {{tp|p=27037190|t=2016. Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo |pdf=|usr=}}{{27037190}} gab.com Text Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27037190 #FOAvip Few apoptotic corpses are seen even in tissues with high cellular turnover leading to the notion that the capacity for engulfment in vivo is vast. Whether corpse clearance can be enhanced in vivo for potential benefit is not known. In a colonic inflammation model, we noted that the expression of the phagocytic receptor Bai1 was progressively downmodulated. Consistent with this, BAI1-deficient mice had more pronounced colitis and lower survival, with many uncleared apoptotic corpses and inflammatory cytokines within the colonic epithelium. When we engineered and tested transgenic mice overexpressing BAI1, these had fewer apoptotic cells, reduced inflammation, and attenuated disease. Boosting BAI1-mediated uptake by intestinal epithelial cells (rather than myeloid cells) was important in attenuating inflammation. A signaling-deficient BAI1 transgene could not provide a similar benefit. Collectively, these complementary genetic approaches showed that cell clearance could be boosted in vivo, with potential to regulate tissue inflammation in specific contexts. Twit Text FOAVip Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27037190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27037190 #FOAvip English Wikipedia <ref>{{Cite pmid|27037190}}</ref> Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo #MMPMID27037190 Lee CS; Penberthy KK; Wheeler KM; Juncadella IJ; Vandenabeele P; Lysiak JJ; Ravichandran KS Immunity 2016[Apr]; 44 (4): 807-20 PMID27037190show ga Few apoptotic corpses are seen even in tissues with high cellular turnover leading to the notion that the capacity for engulfment in vivo is vast. Whether corpse clearance can be enhanced in vivo for potential benefit is not known. In a colonic inflammation model, we noted that the expression of the phagocytic receptor Bai1 was progressively downmodulated. Consistent with this, BAI1-deficient mice had more pronounced colitis and lower survival, with many uncleared apoptotic corpses and inflammatory cytokines within the colonic epithelium. When we engineered and tested transgenic mice overexpressing BAI1, these had fewer apoptotic cells, reduced inflammation, and attenuated disease. Boosting BAI1-mediated uptake by intestinal epithelial cells (rather than myeloid cells) was important in attenuating inflammation. A signaling-deficient BAI1 transgene could not provide a similar benefit. Collectively, these complementary genetic approaches showed that cell clearance could be boosted in vivo, with potential to regulate tissue inflammation in specific contexts. äBoosting apoptotic cell clearance by colonic epithelial cells attenuat(epmc).pdf DeepDyve Pubget Overpricing