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10.1097/MIB.0000000000000750

http://scihub22266oqcxt.onion/10.1097/MIB.0000000000000750
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C4838534!4838534!27070911
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suck abstract from ncbi


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pmid27070911      Inflamm+Bowel+Dis 2016 ; 22 (5): 1137-50
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  • Current understanding of dysbiosis in disease in human and animal models #MMPMID27070911
  • DeGruttola AK; Low D; Mizoguchi A; Mizoguchi E
  • Inflamm Bowel Dis 2016[May]; 22 (5): 1137-50 PMID27070911show ga
  • Inflammatory bowel disease (IBD) is an intestinal inflammatory condition that affects over two million people in the United States. Although the etiology and pathogenesis of IBD are still largely unknown, dysregulated host/enteric microbial interactions are requisite for the development of IBD. So far, many researchers have tried to identify a precise relationship between IBD and an imbalance of the intestinal microbiota, termed ?dysbiosis?. In spite of the extensive efforts, it is still largely unknown about the interplay among microbes, their hosts, and their environments, and whether dysbiosis is a causal factor or an effect of IBD. Recently, deep-sequencing analyses of the microbiota in IBD patients have been instrumental in characterizing the strong association between dysbiosis and IBD development, although it is still unable to identify specific-associated species level changes in most cases. Based on many recent reports, dysbiosis of the commensal microbiota is implicated in the pathogenesis of several diseases, including IBD, obesity, and allergic disorders, in both human and animal models.In this review article, we have focused on explaining the multiple types of dysbiosis, as well as dysbiosis-related diseases and potential treatments in order to apply this knowledge to understand a possible cause and potentially find therapeutic strategies for IBD as well as the other dysbiosis-related diseases.
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