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10.1016/j.gene.2016.03.017 http://scihub22266oqcxt.onion/10.1016/j.gene.2016.03.017 C4838531!4838531!26997260     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene 2016 ; 585 (1): 128-34 Nephropedia Template TP {{tp|p=26997260|t=2016. PELP1: Structure, biological function and clinical significance |pdf=|usr=}}{{26997260}} gab.com Text PELP1: Structure, biological function and clinical significance JO: Gene http://www.kidney.de/pget.php?&tw=1&pmid=26997260 #FOAvip Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein that functions as a coregulator of several transcription factors and nuclear receptors. Notably, the PELP1 protein has a histone-binding domain, recognizes histone modifications and interacts with several chromatin-modifying complexes. PELP1 serves as a substrate of multitude of kinases, and phosphorylation regulates its functions in various complexes. Further, PELP1 plays essential roles in several pathways including hormonal signaling, cell cycle progression, ribosomal biogenesis, and the DNA damage response. PELP1 expression is upregulated in several cancers, its deregulation contributes to therapy resistance, and it is a prognostic biomarker for breast cancer survival. Recent evidence suggests that PELP1 represents a novel therapeutic target for many hormonal cancers. In this review, we summarized the emerging biological properties and functions of PELP1. Twit Text FOAVip PELP1: Structure, biological function and clinical significance ????Gene http://www.kidney.de/pget.php?&tw=1&pmid=26997260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26997260 #FOAvip English Wikipedia <ref>{{Cite pmid|26997260}}</ref> PELP1: Structure, biological function and clinical significance #MMPMID26997260 Sareddy GR; Vadlamudi RK Gene 2016[Jul]; 585 (1): 128-34 PMID26997260show ga Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein that functions as a coregulator of several transcription factors and nuclear receptors. Notably, the PELP1 protein has a histone-binding domain, recognizes histone modifications and interacts with several chromatin-modifying complexes. PELP1 serves as a substrate of multitude of kinases, and phosphorylation regulates its functions in various complexes. Further, PELP1 plays essential roles in several pathways including hormonal signaling, cell cycle progression, ribosomal biogenesis, and the DNA damage response. PELP1 expression is upregulated in several cancers, its deregulation contributes to therapy resistance, and it is a prognostic biomarker for breast cancer survival. Recent evidence suggests that PELP1 represents a novel therapeutic target for many hormonal cancers. In this review, we summarized the emerging biological properties and functions of PELP1. äPELP1: Structure, biological function and clinical significance (epmc).pdf DeepDyve Pubget Overpricing