Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.immuni.2016.01.011 http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.01.011 C4838502!4838502 !26944202     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26944202 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2016 ; 44 (4 ): 769-81 Nephropedia Template TP {{tp|p=26944202 |t=2016. Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory |pdf=|usr=}}{{26944202 }} gab.com Text Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26944202 #FOAvip Somatic hypermutation (SHM) and class-switch recombination (CSR) increase the affinity and diversify the effector functions of antibodies during immune responses. Although SHM and CSR are fundamentally different, their independent roles in regulating B cell fate have been difficult to uncouple because a single enzyme, activation-induced cytidine deaminase (encoded by Aicda), initiates both reactions. Here, we used a combination of Aicda and antibody mutant alleles that separate the effects of CSR and SHM on polyclonal immune responses. We found that class-switching to IgG1 biased the fate choice made by B cells, favoring the plasma cell over memory cell fate without significantly affecting clonal expansion in the germinal center (GC). In contrast, SHM reduced the longevity of memory B cells by creating polyreactive specificities that were selected against over time. Our data define the independent contributions of SHM and CSR to the generation and persistence of memory in the antibody system. Twit Text FOAVip Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26944202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26944202 #FOAvip English Wikipedia <ref>{{Cite pmid|26944202 }}</ref> Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory #MMPMID26944202 Gitlin AD ; von Boehmer L ; Gazumyan A ; Shulman Z ; Oliveira TY ; Nussenzweig MC Immunity 2016[Apr]; 44 (4 ): 769-81 PMID26944202 show ga Somatic hypermutation (SHM) and class-switch recombination (CSR) increase the affinity and diversify the effector functions of antibodies during immune responses. Although SHM and CSR are fundamentally different, their independent roles in regulating B cell fate have been difficult to uncouple because a single enzyme, activation-induced cytidine deaminase (encoded by Aicda), initiates both reactions. Here, we used a combination of Aicda and antibody mutant alleles that separate the effects of CSR and SHM on polyclonal immune responses. We found that class-switching to IgG1 biased the fate choice made by B cells, favoring the plasma cell over memory cell fate without significantly affecting clonal expansion in the germinal center (GC). In contrast, SHM reduced the longevity of memory B cells by creating polyreactive specificities that were selected against over time. Our data define the independent contributions of SHM and CSR to the generation and persistence of memory in the antibody system. |AICDA (Activation-Induced Cytidine Deaminase) [MESH] |Animals [MESH] |B-Lymphocytes/cytology/*immunology [MESH] |Cell Differentiation/immunology [MESH] |Cytidine Deaminase/*genetics [MESH] |Germinal Center/immunology/metabolism [MESH] |Immunoglobulin Class Switching/genetics/*immunology [MESH] |Immunoglobulin G/genetics/immunology [MESH] |Immunologic Memory/*immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH]Independent Roles of Switching and Hypermutation in the Development an(epmc).pdf DeepDyve Pubget Overpricing