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10.1007/s12195-016-0429-8 http://scihub22266oqcxt.onion/10.1007/s12195-016-0429-8 C4838400!4838400!27110295     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Bioeng 2016 ; 9 (1): 73-84 Nephropedia Template TP {{tp|p=27110295|t=2016. Physical and Chemical Signals That Promote Vascularization of Capillary-Scale Channels |pdf=|usr=}}{{27110295}} gab.com Text Physical and Chemical Signals That Promote Vascularization of Capillary-Scale Channels JO: Cell Mol Bioeng http://www.kidney.de/pget.php?&tw=1&pmid=27110295 #FOAvip Proper vascularization remains critical to the clinical application of engineered tissues. To engineer microvessels in vitro, we and others have delivered endothelial cells through preformed channels into patterned extracellular matrix-based gels. This approach has been limited by the size of endothelial cells in suspension, and results in plugging of channels below ~30 ?m in diameter. Here, we examine physical and chemical signals that can augment direct seeding, with the aim of rapidly vascularizing capillary-scale channels. By studying tapered microchannels in type I collagen gels under various conditions, we establish that stiff scaffolds, forward pressure, and elevated cyclic AMP levels promote endothelial stability and that reverse pressure promotes endothelial migration. We applied these results to uniform 20-?m-diameter channels and optimized the magnitudes of pressure, flow, and shear stress to best support endothelial migration and vascular stability. This vascularization strategy is able to form millimeter-long perfusable capillaries within three days. Our results indicate how to manipulate the physical and chemical environment to promote rapid vascularization of capillary-scale channels within type I collagen gels. Twit Text FOAVip Physical and Chemical Signals That Promote Vascularization of Capillary-Scale Channels ????Cell Mol Bioeng http://www.kidney.de/pget.php?&tw=1&pmid=27110295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27110295 #FOAvip English Wikipedia <ref>{{Cite pmid|27110295}}</ref> Physical and Chemical Signals That Promote Vascularization of Capillary-Scale Channels #MMPMID27110295 Linville RM; Boland NF; Covarrubias G; Price GM; Tien J Cell Mol Bioeng 2016[Mar]; 9 (1): 73-84 PMID27110295show ga Proper vascularization remains critical to the clinical application of engineered tissues. To engineer microvessels in vitro, we and others have delivered endothelial cells through preformed channels into patterned extracellular matrix-based gels. This approach has been limited by the size of endothelial cells in suspension, and results in plugging of channels below ~30 ?m in diameter. Here, we examine physical and chemical signals that can augment direct seeding, with the aim of rapidly vascularizing capillary-scale channels. By studying tapered microchannels in type I collagen gels under various conditions, we establish that stiff scaffolds, forward pressure, and elevated cyclic AMP levels promote endothelial stability and that reverse pressure promotes endothelial migration. We applied these results to uniform 20-?m-diameter channels and optimized the magnitudes of pressure, flow, and shear stress to best support endothelial migration and vascular stability. This vascularization strategy is able to form millimeter-long perfusable capillaries within three days. Our results indicate how to manipulate the physical and chemical environment to promote rapid vascularization of capillary-scale channels within type I collagen gels. äPhysical and Chemical Signals That Promote Vascularization of Capillar(epmc).pdf DeepDyve Pubget Overpricing