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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Drug+Targets
2015 ; 16
(12
): 1332-46
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Identifying Novel Targets for Treatment of Liver Fibrosis: What Can We Learn from
Injured Tissues which Heal Without a Scar?
#MMPMID26302807
Pritchard MT
; McCracken JM
Curr Drug Targets
2015[]; 16
(12
): 1332-46
PMID26302807
show ga
The liver is unique in that it is able to regenerate. This regeneration occurs
without formation of a scar in the case of non-iterative hepatic injury. However,
when the liver is exposed to chronic liver injury, the purely regenerative
process fails and excessive extracellular matrix proteins are deposited in place
of normal liver parenchyma. While much has been discovered in the past three
decades, insights into fibrotic mechanisms have not yet lead to effective
therapies; liver transplant remains the only cure for advanced liver disease. In
an effort to broaden the collection of possible therapeutic targets, this review
will compare and contrast the liver wound healing response to that found in two
types of wound healing: scarless wound healing of fetal skin and oral mucosa and
scar-forming wound healing found in adult skin. This review will examine wound
healing in the liver and the skin in relation to the role of humoral and cellular
factors, as well as the extracellular matrix, in this process. While several
therapeutic targets are similar between fibrotic liver and adult skin wound
healing, others are unique and represent novel areas for hepatic anti-fibrotic
research. In particular, investigations into the role of hyaluronan in liver
fibrosis and fibrosis resolution are warranted.
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