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2016 ; 13
(5
): 4238-44
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Galangin inhibits cell invasion by suppressing the epithelial-mesenchymal
transition and inducing apoptosis in renal cell carcinoma
#MMPMID27035542
Cao J
; Wang H
; Chen F
; Fang J
; Xu A
; Xi W
; Zhang S
; Wu G
; Wang Z
Mol Med Rep
2016[May]; 13
(5
): 4238-44
PMID27035542
show ga
Galangin, a flavonoid extracted from the root of the Alpinia officinarum Hence,
has been shown to have anticancer properties against several types of cancer
cells. However, the influence of galangin on human renal cancer cells remains to
be elucidated. In the present study, proliferation of 786?0 and Caki?1 cells was
suppressed following exposure to various doses of galangin. Cell invasion and
wound healing assays were used to observe the effect of galangin on invasion and
migration. The results demonstrated that Galangin inhibited cell invasion by
suppressing the epithelial mesenchymal transition (EMT), with an increase in the
expression of E?cadherin and decreased expression levels of N?cadherin and
vimentin. The apoptosis induced by galangin was analyzed by flow cytometry. The
results revealed that galangin induced apoptosis in a dose?dependent manner. The
accumulation of reactive oxygen species (ROS) is an important contributing factor
for the apoptosis of various types of cancer cell. The
dichlorofluorescein-diacetate method was used to determine the level of ROS.
Galangin induced the accumulation of intracellular ROS and malondialdehyde, and
decreased the activities of total antioxidant and superoxide dismutase in renal
cell carcinoma cells. Galangin exerted an antiproliferative effect and inhibited
renal cell carcinoma invasion by suppressing the EMT. This treatment also induced
apoptosis, accompanied by the production of ROS. Therefore, the present data
suggested that galangin may have beneficial effects by preventing renal cell
carcinoma growth, inhibiting cell invasion via the EMT and inducing cell
apoptosis.
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