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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Gastroenterol+Rep
2016 ; 18
(4
): 17
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Gastrointestinal Disorders Associated with Common Variable Immune Deficiency
(CVID) and Chronic Granulomatous Disease (CGD)
#MMPMID26951230
Uzzan M
; Ko HM
; Mehandru S
; Cunningham-Rundles C
Curr Gastroenterol Rep
2016[Apr]; 18
(4
): 17
PMID26951230
show ga
Common variable immune deficiency (CVID) and chronic granulomatous disease (CGD)
are two of the well-characterized primary immune deficiencies with distinct
pathologic defects. While CVID is predominantly a disorder of the adaptive immune
system, in CGD, innate immunity is impaired. In both syndromes, the clinical
manifestations include an increased susceptibility to infections and a number of
non-infectious, inflammatory conditions including systemic autoimmunity, as well
as organ-specific pathology. Among the organ-associated disorders,
gastrointestinal (GI) manifestations are one of the most intractable. As such,
non-infectious inflammatory disorders of the GI tract are clinically challenging
as they have protean manifestations, often resembling inflammatory bowel disease
(IBD) or celiac disease, are notoriously difficult to treat, and hence are
associated with significant morbidity and mortality. Therefore, assessing the
pathogenesis and defining appropriate therapeutic approaches for GI disease in
patients with CVID and CGD is imperative.