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2015 ; 12
(10
): 1579-82
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Combining glucose monitoring and insulin delivery into a single device: current
progress and ongoing challenges of the artificial pancreas
#MMPMID26389567
Ang KH
; Tamborlane WV
; Weinzimer SA
Expert Opin Drug Deliv
2015[]; 12
(10
): 1579-82
PMID26389567
show ga
Despite the widespread availability of insulin pumps, continuous glucose sensors,
and insulin analogs with rapid-acting pharmacokinetic profiles, most people with
type 1 diabetes fail to meet recommended glycemic targets, rates of severe
hypoglycemia remain unacceptably high, and the burden of care on patients and
loved ones exacts an enormous psychosocial toll. The combination of continuous
glucose monitoring with insulin delivery into an integrated automated system
promises to improve diabetes control while at the same time reduce the burden of
care. A wide variety of automated insulin delivery systems, ranging in scope from
simple pump suspension to reduce hypoglycemia, to complex multiple hormone
systems under separate regulation and delivery, have been studied in both
controlled inpatient settings and more free-ranging outpatient environments.
Preliminary findings have been positive, with most studies demonstrating
reduction in overall glucose levels, increased time-in-target range, and
reductions in exposure to hypoglycemia. As these systems move closer to
commercialization, the focus of ongoing efforts will need to address the
continuing challenges of sensor accuracy and reliability, connectivity issues,
and human factors considerations.
|*Blood Glucose Self-Monitoring
[MESH]
|*Drug Delivery Systems
[MESH]
|*Insulin Infusion Systems
[MESH]
|*Pancreas, Artificial
[MESH]
|Blood Glucose/metabolism
[MESH]
|Diabetes Mellitus, Type 1/blood/drug therapy
[MESH]