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Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell
Invasion via Inhibition of Hippo Pathway
#MMPMID27094683
Wang Y
; Liu J
; Ying X
; Lin PC
; Zhou BP
Sci Rep
2016[Apr]; 6
(?): 24606
PMID27094683
show ga
Twist is a key transcription factor for Epithelial-mesenchymal transition (EMT),
which is a cellular de-differentiation program that promotes invasion and
metastasis, confers tumor cells with cancer stem cell (CSC)-like characteristics,
and increases therapeutic resistance. However, the mechanisms that facilitate the
functions of Twist remain unclear. Here we report that Twist overexpression
increased expression of PAR1, an upstream regulator of the Hippo pathway; PAR1
promotes invasion, migration, and CSC-like properties in breast cancer by
activating the transcriptional co-activator TAZ. Our study indicates that Hippo
pathway inhibition is required for the increased migratory and invasiveness
ability of breast cancer cells in Twist-mediated EMT.
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