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High density lipoprotein and metabolic disease: Potential benefits of restoring
its functional properties
#MMPMID27110484
Klancic T
; Woodward L
; Hofmann SM
; Fisher EA
Mol Metab
2016[May]; 5
(5
): 321-327
PMID27110484
show ga
BACKGROUND: High density lipoproteins (HDLs) are thought to be atheroprotective
and to reduce the risk of cardiovascular disease (CVD). Besides their
antioxidant, antithrombotic, anti-inflammatory, anti-apoptotic properties in the
vasculature, HDLs also improve glucose metabolism in skeletal muscle. SCOPE OF
THE REVIEW: Herein, we review the functional role of HDLs to improve metabolic
disorders, especially those involving insulin resistance and to induce regression
of CVD with a particular focus on current pharmacological treatment options as
well as lifestyle interventions, particularly exercise. MAJOR CONCLUSIONS:
Functional properties of HDLs continue to be considered important mediators to
reverse metabolic dysfunction and to regress atherosclerotic cardiovascular
disease. Lifestyle changes are often recommended to reduce the risk of CVD, with
exercise being one of the most important of these. Understanding how exercise
improves HDL function will likely lead to new approaches to battle the expanding
burden of obesity and the metabolic syndrome.
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