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2016 ; 2016
(ä): 8413768
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IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric
Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis
#MMPMID27143819
Khawar MB
; Abbasi MH
; Sheikh N
Mediators Inflamm
2016[]; 2016
(ä): 8413768
PMID27143819
show ga
A vast variety of nonstructural proteins have been studied for their key roles
and involvement in a number of biological phenomenona. Interleukin-32 is a novel
cytokine whose presence has been confirmed in most of the mammals except rodents.
The IL-32 gene was identified on human chromosome 16 p13.3. The gene has eight
exons and nine splice variants, namely, IL-32?, IL-32?, IL-32?, IL-32?, IL-32?,
IL-32?, IL-32?, IL-32?, and IL-32s. It was found to induce the expression of
various inflammatory cytokines including TNF-?, IL-6, and IL-1? as well as
macrophage inflammatory protein-2 (MIP-2) and has been reported previously to be
involved in the pathogenesis and progression of a number of inflammatory
disorders, namely, inflammatory bowel disease (IBD), gastric inflammation and
cancer, rheumatoid arthritis, and chronic obstructive pulmonary disease (COPD).
In the current review, we have highlighted the involvement of IL-32 in gastric
cancer, gastric inflammation, and chronic rhinosinusitis. We have also tried to
explore various mechanisms suspected to induce the expression of this
extraordinary cytokine as well as various mechanisms of action employed by IL-32
during the mediation and progression of the above said problems.