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2016 ; 2016
(ä): 2795090
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The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role
in Progression and Treatment of Human Diseases
#MMPMID27143992
Tan HY
; Wang N
; Li S
; Hong M
; Wang X
; Feng Y
Oxid Med Cell Longev
2016[]; 2016
(ä): 2795090
PMID27143992
show ga
High heterogeneity of macrophage is associated with its functions in polarization
to different functional phenotypes depending on environmental cues. Macrophages
remain in balanced state in healthy subject and thus macrophage polarization may
be crucial in determining the tissue fate. The two distinct populations,
classically M1 and alternatively M2 activated, representing the opposing ends of
the full activation spectrum, have been extensively studied for their
associations with several disease progressions. Accumulating evidences have
postulated that the redox signalling has implication in macrophage polarization
and the key roles of M1 and M2 macrophages in tissue environment have provided
the clue for the reasons of ROS abundance in certain phenotype. M1 macrophages
majorly clearing the pathogens and ROS may be crucial for the regulation of M1
phenotype, whereas M2 macrophages resolve inflammation which favours oxidative
metabolism. Therefore how ROS play its role in maintaining the homeostatic
functions of macrophage and in particular macrophage polarization will be
reviewed here. We also review the biology of macrophage polarization and the
disturbance of M1/M2 balance in human diseases. The potential therapeutic
opportunities targeting ROS will also be discussed, hoping to provide insights
for development of target-specific delivery system or immunomodulatory
antioxidant for the treatment of ROS-related diseases.
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