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2016 ; 2016
(ä): 8493767
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Interleukin-2/Anti-Interleukin-2 Immune Complex Attenuates Cardiac Remodeling
after Myocardial Infarction through Expansion of Regulatory T Cells
#MMPMID27144181
Zeng Z
; Yu K
; Chen L
; Li W
; Xiao H
; Huang Z
J Immunol Res
2016[]; 2016
(ä): 8493767
PMID27144181
show ga
CD4+CD25+Foxp3+ regulatory T cells (Treg cells) have protective effects in wound
healing and adverse ventricular remodeling after myocardial infarction (MI). We
hypothesize that the interleukin- (IL-) 2 complex comprising the recombinant
mouse IL-2/anti-IL-2 mAb (JES6-1) attenuates cardiac remodeling after MI through
the expansion of Treg. Mice were subjected to surgical left anterior descending
coronary artery ligation and treated with either PBS or IL-2 complex. The IL-2
complex significantly attenuates ventricular remodeling, as demonstrated by
reduced infarct size, improved left ventricular (LV) function, and attenuated
cardiomyocyte apoptosis. The IL-2 complex increased the percentage of
CD4+CD25+Foxp3+ Treg cells, which may be recruited to the infarcted heart, and
decreased the frequencies of IFN-?- and IL-17-producing CD4+ T helper (Th) cells
among the CD4+Foxp3- T cells in the spleen. Furthermore, the IL-2 complex
inhibited the gene expression of proinflammatory cytokines as well as macrophage
infiltrates in the infarcted myocardium and induced the differentiation of
macrophages from M1 to M2 phenotype in border zone of infarcted myocardium. Our
studies indicate that the IL-2 complex may serve as a promising therapeutic
approach to attenuate adverse remodeling after MI through expanding Treg cells
specifically.