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10.1038/ni.3408 http://scihub22266oqcxt.onion/10.1038/ni.3408 C4837106!4837106 !27019226     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27019226 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2016 ; 17 (5 ): 545-55 Nephropedia Template TP {{tp|p=27019226 |t=2016. Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance |pdf=|usr=}}{{27019226 }} gab.com Text Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27019226 #FOAvip Oral tolerance prevents pathological inflammatory responses to innocuous foreign antigens by peripheral regulatory T cells (pT(reg) cells). However, whether a particular subset of antigen-presenting cells (APCs) is required during dietary antigen exposure for the 'instruction' of naive CD4(+) T cells to differentiate into pT(reg) cells has not been defined. Using myeloid lineage-specific APC depletion in mice, we found that monocyte-derived APCs were dispensable, while classical dendritic cells (cDCs) were critical, for pT(reg) cell induction and oral tolerance. CD11b(-) cDCs from the gut-draining lymph nodes efficiently induced pT(reg) cells and, conversely, loss of transcription factor IRF8-dependent CD11b(-) cDCs impaired their polarization, although oral tolerance remained intact. These data reveal the hierarchy of cDC subsets in the induction of pT(reg) cells and their redundancy during the development of oral tolerance. Twit Text FOAVip Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27019226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27019226 #FOAvip English Wikipedia <ref>{{Cite pmid|27019226 }}</ref> Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance #MMPMID27019226 Esterházy D ; Loschko J ; London M ; Jove V ; Oliveira TY ; Mucida D Nat Immunol 2016[May]; 17 (5 ): 545-55 PMID27019226 show ga Oral tolerance prevents pathological inflammatory responses to innocuous foreign antigens by peripheral regulatory T cells (pT(reg) cells). However, whether a particular subset of antigen-presenting cells (APCs) is required during dietary antigen exposure for the 'instruction' of naive CD4(+) T cells to differentiate into pT(reg) cells has not been defined. Using myeloid lineage-specific APC depletion in mice, we found that monocyte-derived APCs were dispensable, while classical dendritic cells (cDCs) were critical, for pT(reg) cell induction and oral tolerance. CD11b(-) cDCs from the gut-draining lymph nodes efficiently induced pT(reg) cells and, conversely, loss of transcription factor IRF8-dependent CD11b(-) cDCs impaired their polarization, although oral tolerance remained intact. These data reveal the hierarchy of cDC subsets in the induction of pT(reg) cells and their redundancy during the development of oral tolerance. |Animals [MESH] |Antigen-Presenting Cells/immunology/metabolism [MESH] |Antigens/*immunology [MESH] |CD11b Antigen/immunology/metabolism [MESH] |CD4-Positive T-Lymphocytes/immunology/metabolism [MESH] |Cell Differentiation/genetics/immunology [MESH] |Cells, Cultured [MESH] |Coculture Techniques [MESH] |Dendritic Cells/*immunology/metabolism [MESH] |Diet [MESH] |Flow Cytometry [MESH] |Immune Tolerance/genetics/*immunology [MESH] |Immunization/methods [MESH] |Interferon Regulatory Factors/genetics/immunology/metabolism [MESH] |Lymph Nodes/immunology/metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |T-Lymphocytes, Regulatory/*immunology/metabolism [MESH]Classical dendritic cells are required for dietary antigen-mediated in(epmc).pdf DeepDyve Pubget Overpricing