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10.1038/nchembio.2042 http://scihub22266oqcxt.onion/10.1038/nchembio.2042 C4836974!4836974!26974814     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26974814&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Chem+Biol 2016 ; 12 (5): 317-23 Nephropedia Template TP {{tp|p=26974814|t=2016. Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes |pdf=|usr=}}{{26974814}} gab.com Text Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes JO: Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=26974814 #FOAvip Epigenetic gene regulation is a dynamic process orchestrated by chromatin-modifying enzymes. Many of these master regulators exert their function through covalent modification of DNA and histone proteins. Aberrant epigenetic processes have been implicated in the pathophysiology of multiple human diseases. Small-molecule inhibitors have been essential to advancing our understanding of the underlying molecular mechanisms of epigenetic processes. However, the resolution offered by small molecules is often insufficient to manipulate epigenetic processes with high spatio-temporal control. Here, we present a novel and generalizable approach, referred to as ?Chemo-Optical Modulation of Epigenetically-regulated Transcription? (COMET), enabling high-resolution, optical control of epigenetic mechanisms based on photochromic inhibitors of human histone deacetylases using visible light. COMET probes may translate into novel therapeutic strategies for diseases where conditional and selective epigenome modulation is required. Twit Text FOAVip Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes ????Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=26974814 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26974814 #FOAvip English Wikipedia <ref>{{Cite pmid|26974814}}</ref> Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes #MMPMID26974814 Reis SA; Ghosh B; Hendricks JA; Szantai-Kis DM; Törk L; Ross KN; Lamb J; Read-Button W; Zheng B; Wang H; Salthouse C; Haggarty SJ; Mazitschek R Nat Chem Biol 2016[May]; 12 (5): 317-23 PMID26974814show ga Epigenetic gene regulation is a dynamic process orchestrated by chromatin-modifying enzymes. Many of these master regulators exert their function through covalent modification of DNA and histone proteins. Aberrant epigenetic processes have been implicated in the pathophysiology of multiple human diseases. Small-molecule inhibitors have been essential to advancing our understanding of the underlying molecular mechanisms of epigenetic processes. However, the resolution offered by small molecules is often insufficient to manipulate epigenetic processes with high spatio-temporal control. Here, we present a novel and generalizable approach, referred to as ?Chemo-Optical Modulation of Epigenetically-regulated Transcription? (COMET), enabling high-resolution, optical control of epigenetic mechanisms based on photochromic inhibitors of human histone deacetylases using visible light. COMET probes may translate into novel therapeutic strategies for diseases where conditional and selective epigenome modulation is required. äLight Controlled Modulation of Gene Expression by Chemical Optoepigene(epmc).pdf DeepDyve Pubget Overpricing