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10.1080/21688370.2015.1138017 http://scihub22266oqcxt.onion/10.1080/21688370.2015.1138017 C4836485!4836485!27141420     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Tissue+Barriers 2016 ; 4 (1): ä Nephropedia Template TP {{tp|p=27141420|t=2016. Tight junction modulation of the blood brain barrier: CNS delivery of small molecules |pdf=|usr=}}{{27141420}} gab.com Text Tight junction modulation of the blood brain barrier: CNS delivery of small molecules JO: Tissue Barriers http://www.kidney.de/pget.php?&tw=1&pmid=27141420 #FOAvip The blood brain barrier (BBB) represents a major obstacle for targeted drug delivery to the brain for the treatment of central nervous system (CNS) disorders. Significant advances in barrier research over the past decade has led to the discovery of an increasing number of structural and regulatory proteins in tight junctions (TJ) and adherens junctions (AJ). These discoveries are providing the framework for the development of novel TJ modulators which can act specifically and temporarily to alter BBB function and regulate paracellular uptake of molecules. TJ modulators that have shown therapeutic potential in preclinical models include claudin-5 and occludin siRNAs, peptides derived from zonula occludens toxin as well as synthetic peptides targeting the extracellular loops of TJs. Adding to the array of modulating agents are novel mechanisms of BBB regulation such as focused ultrasound (FUS). This review will give a succinct overview of BBB biology and TJ modulation in general. Novel insights into BBB regulation in health and disease will also be summarized. Twit Text FOAVip Tight junction modulation of the blood brain barrier: CNS delivery of small molecules ????Tissue Barriers http://www.kidney.de/pget.php?&tw=1&pmid=27141420 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27141420 #FOAvip English Wikipedia <ref>{{Cite pmid|27141420}}</ref> Tight junction modulation of the blood brain barrier: CNS delivery of small molecules #MMPMID27141420 Greene C; Campbell M Tissue Barriers 2016[Jan]; 4 (1): ä PMID27141420show ga The blood brain barrier (BBB) represents a major obstacle for targeted drug delivery to the brain for the treatment of central nervous system (CNS) disorders. Significant advances in barrier research over the past decade has led to the discovery of an increasing number of structural and regulatory proteins in tight junctions (TJ) and adherens junctions (AJ). These discoveries are providing the framework for the development of novel TJ modulators which can act specifically and temporarily to alter BBB function and regulate paracellular uptake of molecules. TJ modulators that have shown therapeutic potential in preclinical models include claudin-5 and occludin siRNAs, peptides derived from zonula occludens toxin as well as synthetic peptides targeting the extracellular loops of TJs. Adding to the array of modulating agents are novel mechanisms of BBB regulation such as focused ultrasound (FUS). This review will give a succinct overview of BBB biology and TJ modulation in general. Novel insights into BBB regulation in health and disease will also be summarized. äTight junction modulation of the blood brain barrier: CNS delivery of (epmc).pdf DeepDyve Pubget Overpricing