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10.1080/21688370.2016.1142493 http://scihub22266oqcxt.onion/10.1080/21688370.2016.1142493 C4836466!4836466!27141422     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Tissue+Barriers 2016 ; 4 (1): ä Nephropedia Template TP {{tp|p=27141422|t=2016. Microfluidic organ-on-chip technology for blood-brain barrier research |pdf=|usr=}}{{27141422}} gab.com Text Microfluidic organ-on-chip technology for blood-brain barrier research JO: Tissue Barriers http://www.kidney.de/pget.php?&tw=1&pmid=27141422 #FOAvip Organs-on-chips are a new class of microengineered laboratory models that combine several of the advantages of current in vivo and in vitro models. In this review, we summarize the advances that have been made in the development of organ-on-chip models of the blood-brain barrier (BBBs-on-chips) and the challenges that are still ahead. The BBB is formed by specialized e3ndothelial cells and separates blood from brain tissue. It protects the brain from harmful compounds from the blood and provides homeostasis for optimal neuronal function. Studying BBB function and dysfunction is important for drug development and biomedical research. Microfluidic BBBs-on-chips enable real-time study of (human) cells in an engineered physiological microenvironment, for example incorporating small geometries and fluid flow as well as sensors. Examples of BBBs-on-chips in literature already show the potential of more realistic microenvironments and the study of organ-level functions. A key challenge in the field of BBB-on-chip development is the current lack of standardized quantification of parameters such as barrier permeability and shear stress. This limits the potential for direct comparison of the performance of different BBB-on-chip models to each other and existing models. We give recommendations for further standardization in model characterization and conclude that the rapidly emerging field of BBB-on-chip models holds great promise for further studies in BBB biology and drug development. Twit Text FOAVip Microfluidic organ-on-chip technology for blood-brain barrier research ????Tissue Barriers http://www.kidney.de/pget.php?&tw=1&pmid=27141422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27141422 #FOAvip English Wikipedia <ref>{{Cite pmid|27141422}}</ref> Microfluidic organ-on-chip technology for blood-brain barrier research #MMPMID27141422 van der Helm MW; van der Meer AD; Eijkel JCT; van den Berg A; Segerink LI Tissue Barriers 2016[Jan]; 4 (1): ä PMID27141422show ga Organs-on-chips are a new class of microengineered laboratory models that combine several of the advantages of current in vivo and in vitro models. In this review, we summarize the advances that have been made in the development of organ-on-chip models of the blood-brain barrier (BBBs-on-chips) and the challenges that are still ahead. The BBB is formed by specialized e3ndothelial cells and separates blood from brain tissue. It protects the brain from harmful compounds from the blood and provides homeostasis for optimal neuronal function. Studying BBB function and dysfunction is important for drug development and biomedical research. Microfluidic BBBs-on-chips enable real-time study of (human) cells in an engineered physiological microenvironment, for example incorporating small geometries and fluid flow as well as sensors. Examples of BBBs-on-chips in literature already show the potential of more realistic microenvironments and the study of organ-level functions. A key challenge in the field of BBB-on-chip development is the current lack of standardized quantification of parameters such as barrier permeability and shear stress. This limits the potential for direct comparison of the performance of different BBB-on-chip models to each other and existing models. We give recommendations for further standardization in model characterization and conclude that the rapidly emerging field of BBB-on-chip models holds great promise for further studies in BBB biology and drug development. äMicrofluidic organ-on-chip technology for blood-brain barrier research(epmc).pdf DeepDyve Pubget Overpricing