Regulation of cardiomyocyte autophagy by calcium #MMPMID26884385
Shaikh S; Troncoso R; Criollo A; Bravo-Sagua R; García L; Morselli E; Cifuentes M; Quest AFG; Hill JA; Lavandero S
Am J Physiol Endocrinol Metab 2016[Apr]; 310 (8): E587-96 PMID26884385show ga
Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.