Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1152/ajprenal.00502.2015 http://scihub22266oqcxt.onion/10.1152/ajprenal.00502.2015 C4835922!4835922!26719364     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2016 ; 310 (8): F689-96 Nephropedia Template TP {{tp|p=26719364|t=2016. Transforming growth factor-?1 and diabetic nephropathy |pdf=|usr=}}{{26719364}} gab.com Text Transforming growth factor- 1 and diabetic nephropathy JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26719364 #FOAvip Transforming growth factor-?1 (TGF-?1) is established to be involved in the pathogenesis of diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the expression of TGF-?1. TGF-?1 promotes cell hypertrophy and extracellular matrix accumulation in the mesangium, which decreases glomerular filtration rate and leads to chronic renal failure. Recently, TGF-?1 has been demonstrated to regulate urinary albumin excretion by both increasing glomerular permeability and decreasing reabsorption in the proximal tubules. TGF-?1 also increases urinary excretion of water, electrolytes and glucose by suppressing tubular reabsorption in both normal and diabetic conditions. Although TGF-?1 exerts hypertrophic and fibrogenic effects in diabetic nephropathy, whether suppression of the function of TGF-?1 can be an option to prevent or treat the complication is still controversial. This is partly because adrenal production of mineralocorticoids could be augmented by the suppression of TGF-?1. However, differentiating the molecular mechanisms for glomerulosclerosis from those for the suppression of the effects of mineralocorticoids by TGF-?1 may assist in developing novel therapeutic strategies for diabetic nephropathy. In this review, we discuss recent findings on the role of TGF-?1 in diabetic nephropathy. Twit Text FOAVip Transforming growth factor- 1 and diabetic nephropathy ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26719364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26719364 #FOAvip English Wikipedia <ref>{{Cite pmid|26719364}}</ref> Transforming growth factor-?1 and diabetic nephropathy #MMPMID26719364 Chang AS; Hathaway CK; Smithies O; Kakoki M Am J Physiol Renal Physiol 2016[Apr]; 310 (8): F689-96 PMID26719364show ga Transforming growth factor-?1 (TGF-?1) is established to be involved in the pathogenesis of diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the expression of TGF-?1. TGF-?1 promotes cell hypertrophy and extracellular matrix accumulation in the mesangium, which decreases glomerular filtration rate and leads to chronic renal failure. Recently, TGF-?1 has been demonstrated to regulate urinary albumin excretion by both increasing glomerular permeability and decreasing reabsorption in the proximal tubules. TGF-?1 also increases urinary excretion of water, electrolytes and glucose by suppressing tubular reabsorption in both normal and diabetic conditions. Although TGF-?1 exerts hypertrophic and fibrogenic effects in diabetic nephropathy, whether suppression of the function of TGF-?1 can be an option to prevent or treat the complication is still controversial. This is partly because adrenal production of mineralocorticoids could be augmented by the suppression of TGF-?1. However, differentiating the molecular mechanisms for glomerulosclerosis from those for the suppression of the effects of mineralocorticoids by TGF-?1 may assist in developing novel therapeutic strategies for diabetic nephropathy. In this review, we discuss recent findings on the role of TGF-?1 in diabetic nephropathy. äTransforming growth factor-?1 and diabetic nephropathy (epmc).pdf DeepDyve Pubget Overpricing