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2016 ; 11
(ä): 56
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The clinical results of proton beam therapy in patients with idiopathic pulmonary
fibrosis: a single center experience
#MMPMID27090216
Ono T
; Hareyama M
; Nakamura T
; Kimura K
; Hayashi Y
; Azami Y
; Hirose K
; Hatayama Y
; Suzuki M
; Wada H
; Kikuchi Y
; Nemoto K
Radiat Oncol
2016[Apr]; 11
(ä): 56
PMID27090216
show ga
BACKGROUND: The purpose of this study is to retrospectively evaluate the
incidence of lung toxicities after proton beam therapy (PBT) in patients with
idiopathic pulmonary fibrosis (IPF). METHODS: Patients diagnosed with primary
lung cancer or lung metastasis who were treated with PBT between January 2009 and
May 2015 were recruited from our database retrospectively. Cases of pneumonitis
(excluding infection-related pneumonitis) were evaluated using the Common
Terminology Criteria for Adverse Events version 4.0, and the Fletcher-Hugh-Jones
classification of respiratory status was used to evaluate pretreatment and
posttreatment respiratory function. RESULTS: Sixteen IPF patients received PBT
for lung tumors, 15 received PBT for primary lung cancer, and one patient
received PBT for metastasis from lung cancer. The cohort was composed of 14 men
and 2 women, with a median age of 76 years (range: 63-89 years). The median
follow-up time was 12 months (range: 4-39 months). The median dose of PBT was
80.0 Gy relative biological dose effectiveness (RBE) (range: 66.0-86.4 Gy [RBE]).
The cumulative incidence of pneumonitis was 19.8 % (95 % confidence interval
[CI]: 0-40.0 %), including one case of grade 5 pneumonitis. Reduced respiratory
function was observed after PBT in seven patients, including one patient with
pleural dissemination; five of these patients required home oxygen therapy.
CONCLUSIONS: This study suggests that PBT can be performed more safely in IPF
patients than surgery or X-ray irradiation. Although PBT has become a treatment
choice for lung tumors of patients with IPF, the adverse events warrant serious
attention.