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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Pediatr+Endocrinol+Metab
2016 ; 21
(1
): 47-50
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Multiple osteoblastomas in a child with Cushing syndrome due to bilateral adrenal
micronodular hyperplasias
#MMPMID27104180
Yu HW
; Cho WI
; Chung HR
; Choi KH
; Yun S
; Cho HS
; Shin CH
; Yang SW
Ann Pediatr Endocrinol Metab
2016[Mar]; 21
(1
): 47-50
PMID27104180
show ga
Adrenocorticotropin-independent adrenal hyperplasias are rare diseases, which are
classified into macronodular (>1 cm) and micronodular (?1 cm) hyperplasia.
Micronodular adrenal hyperplasia is subdivided into primary pigmented
adrenocortical disease and a limited or nonpigmented form 'micronodular
adrenocortical disease (MAD)', although considerable morphological and genetic
overlap is observed between the 2 groups. We present an unusual case of a
44-month-old girl who was diagnosed with Cushing syndrome due to MAD. She had
presented with spotty pigmentation on her oral mucosa, lips and conjunctivae and
was diagnosed with multiple bone tumors in her femur, pelvis and skull base at
the age of 8 years. Her bone tumor biopsies were compatible with osteoblastoma.
This case highlights the importance of verifying the clinicopathologic
correlation in Cushing syndrome and careful follow-up and screening for
associated diseases.