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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Sleep ä ; 39 (5): 1129-37 Nephropedia Template TP
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K-Complexes: Interaction between the Central and Autonomic Nervous Systems during Sleep #MMPMID26856907
de Zambotti M; Willoughby AR; Franzen PL; Clark DB; Baker FC; Colrain IM
Sleep ä[]; 39 (5): 1129-37 PMID26856907show ga
Study Objectives:: To investigate the relationship between K-complexes (KCs) and cardiac functioning. Methods:: Forty healthy adolescents aged 16?22 y (19 females) participated in the study. Heart rate (HR) fluctuations associated with spontaneous and evoked KCs were investigated on two nights, one with (event-related potential night) and one without auditory tones presented across the night. Results:: There was a clear biphasic cardiac response to evoked and spontaneous KCs, with an initial acceleration in HR followed by a deceleration (P < 0.001). HR acceleration occurred immediately to KCs in response to tones presented in the first third of the interbeat interval, but was delayed a beat when the tone occurred later in the cardiac cycle (P < 0.05). Sex differences were also evident. Pretone baseline HR was higher, and the magnitude of the HR response was blunted and delayed, in female compared to male adolescents (P < 0.001). Also, pretone baseline HR was lower when a tone elicited a KC compared to when it did not (P < 0.001), suggesting that KCs are possibly more likely to be elicited by external stimuli in states of reduced cardiac activation. Conclusions:: The strict dependency observed between KCs and cardiac control indicates a potential role of KCs in modulating the cardiovascular system during sleep. Sex differences in the KC-cardiac response indicate the sensitivity of this measure in capturing sex differences in cardiac regulatory physiology. Citation:: de Zambotti M, Willoughby AR, Franzen PL, Clark DB, Baker FC. K-complexes: interaction between the central and autonomic nervous systems during sleep. SLEEP 2016;39(5):1129?1137.