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10.1016/j.chom.2016.02.012 http://scihub22266oqcxt.onion/10.1016/j.chom.2016.02.012 C4835240!4835240!26962940     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2016 ; 19 (3): 280-91 Nephropedia Template TP {{tp|p=26962940|t=2016. Dissecting How CD4 T Cells Are Lost During HIV Infection |pdf=|usr=}}{{26962940}} gab.com Text Dissecting How CD4 T Cells Are Lost During HIV Infection JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=26962940 #FOAvip Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is this cell death process that drives clinical progression to acquired immune deficiency syndrome (AIDS). Recent studies have highlighted how abortive infection of resting and thus nonpermissive CD4 T cells in lymphoid tissues triggers a lethal innate immune response against the incomplete DNA products generated by inefficient viral reverse transcription in these cells. Sensing of these DNA fragments results in pyroptosis, a highly inflammatory form of programmed cell death, that potentially further perpetuates chronic inflammation and immune activation. As discussed here, these studies cast CD4 T cell death during HIV infection in a different light. Further, they identify drug targets that may be exploited to both block CD4 T cell demise and the chronic inflammatory response generated during pyroptosis. Twit Text FOAVip Dissecting How CD4 T Cells Are Lost During HIV Infection ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=26962940 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26962940 #FOAvip English Wikipedia <ref>{{Cite pmid|26962940}}</ref> Dissecting How CD4 T Cells Are Lost During HIV Infection #MMPMID26962940 Doitsh G; Greene WC Cell Host Microbe 2016[Mar]; 19 (3): 280-91 PMID26962940show ga Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is this cell death process that drives clinical progression to acquired immune deficiency syndrome (AIDS). Recent studies have highlighted how abortive infection of resting and thus nonpermissive CD4 T cells in lymphoid tissues triggers a lethal innate immune response against the incomplete DNA products generated by inefficient viral reverse transcription in these cells. Sensing of these DNA fragments results in pyroptosis, a highly inflammatory form of programmed cell death, that potentially further perpetuates chronic inflammation and immune activation. As discussed here, these studies cast CD4 T cell death during HIV infection in a different light. Further, they identify drug targets that may be exploited to both block CD4 T cell demise and the chronic inflammatory response generated during pyroptosis. äDissecting How CD4 T Cells Are Lost During HIV Infection (epmc).pdf DeepDyve Pubget Overpricing