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10.1016/j.jneumeth.2015.06.011 http://scihub22266oqcxt.onion/10.1016/j.jneumeth.2015.06.011 C4835226!4835226!26093166     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurosci+Methods 2016 ; 260 (ä): 118-24 Nephropedia Template TP {{tp|p=26093166|t=2016. Blood?brain barrier, bulk flow, and interstitial clearance in epilepsy |pdf=|usr=}}{{26093166}} gab.com Text Blood brain barrier, bulk flow, and interstitial clearance in epilepsy JO: J Neurosci Methods http://www.kidney.de/pget.php?&tw=1&pmid=26093166 #FOAvip Understanding the pathophysiology of epilepsy implies elucidating the neurovascular modifications occurring before or at time of seizures. Cerebrovascular dysfunction provokes or sustains seizures and loss of selective blood?brain barrier (BBB) permeability is a modulator of seizure threshold. However, cerebrovascular pathology in epilepsy extends beyond BBB ?leakage? to encompass vascular and parenchymal events. Whenever abnormal accumulation of protein is observed surrounding brain blood vessels, BBB disruption (BBBD) was invoked. Recent clinical and laboratory findings challenged an exclusive role of BBBD in perivascular accumulation of serum-derived products. The circulation of interstitial fluid (ISF) and its bulk flow have emerged as candidate mechanisms which play a role in clearance of CNS waste. Although controversy exists, changes of ISF flow may contribute to CNS disorders through a mechanism encompassing incomplete parenchymal clearance and accompanying accumulation of toxic byproducts.We summarize the evidence in favor and against ISF bulk flow and propose a scenario where abnormal ISF in the epileptic brain allows accumulation of brain protein, sustaining pathophysiology and altering the pharmacology of antiepileptic drugs. We also describe the methods routinely used to dissect out the contribution of BBB-dependent, vascular or paracellular mechanisms to altered neuronal excitability. Twit Text FOAVip Blood brain barrier, bulk flow, and interstitial clearance in epilepsy ????J Neurosci Methods http://www.kidney.de/pget.php?&tw=1&pmid=26093166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26093166 #FOAvip English Wikipedia <ref>{{Cite pmid|26093166}}</ref> Blood?brain barrier, bulk flow, and interstitial clearance in epilepsy #MMPMID26093166 Marchi N; Banjara M; Janigro D J Neurosci Methods 2016[Feb]; 260 (ä): 118-24 PMID26093166show ga Understanding the pathophysiology of epilepsy implies elucidating the neurovascular modifications occurring before or at time of seizures. Cerebrovascular dysfunction provokes or sustains seizures and loss of selective blood?brain barrier (BBB) permeability is a modulator of seizure threshold. However, cerebrovascular pathology in epilepsy extends beyond BBB ?leakage? to encompass vascular and parenchymal events. Whenever abnormal accumulation of protein is observed surrounding brain blood vessels, BBB disruption (BBBD) was invoked. Recent clinical and laboratory findings challenged an exclusive role of BBBD in perivascular accumulation of serum-derived products. The circulation of interstitial fluid (ISF) and its bulk flow have emerged as candidate mechanisms which play a role in clearance of CNS waste. Although controversy exists, changes of ISF flow may contribute to CNS disorders through a mechanism encompassing incomplete parenchymal clearance and accompanying accumulation of toxic byproducts.We summarize the evidence in favor and against ISF bulk flow and propose a scenario where abnormal ISF in the epileptic brain allows accumulation of brain protein, sustaining pathophysiology and altering the pharmacology of antiepileptic drugs. We also describe the methods routinely used to dissect out the contribution of BBB-dependent, vascular or paracellular mechanisms to altered neuronal excitability. äBlood?brain barrier, bulk flow, and interstitial clearance in epilepsy(epmc).pdf DeepDyve Pubget Overpricing