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10.1371/journal.pone.0153165 http://scihub22266oqcxt.onion/10.1371/journal.pone.0153165 C4835109!4835109 !27088599     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27088599 &cmd=llinks): Failed to open stream: HTTP request failed! 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Human Epithelial Cells Discriminate between Commensal and Pathogenic Interactions with Candida albicans |pdf=|usr=}}{{27088599 }} gab.com Text Human Epithelial Cells Discriminate between Commensal and Pathogenic Interactions with Candida albicans JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27088599 #FOAvip The commensal fungus, Candida albicans, can cause life-threatening infections in at risk individuals. C. albicans colonizes mucosal surfaces of most people, adhering to and interacting with epithelial cells. At low concentrations, C. albicans is not pathogenic nor does it cause epithelial cell damage in vitro; at high concentrations, C. albicans causes mucosal infections and kills epithelial cells in vitro. Here we show that while there are quantitative dose-dependent differences in exposed epithelial cell populations, these reflect a fundamental qualitative difference in host cell response to C. albicans. Using transcriptional profiling experiments and real time PCR, we found that wild-type C. albicans induce dose-dependent responses from a FaDu epithelial cell line. However, real time PCR and Western blot analysis using a high dose of various C. albicans strains demonstrated that these dose-dependent responses are associated with ability to promote host cell damage. Our studies support the idea that epithelial cells play a key role in the immune system by monitoring the microbial community at mucosal surfaces and initiating defensive responses when this community is dysfunctional. This places epithelial cells at a pivotal position in the interaction with C. albicans as epithelial cells themselves promote C. albicans stimulated damage. Twit Text FOAVip Human Epithelial Cells Discriminate between Commensal and Pathogenic Interactions with Candida albicans ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27088599 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27088599 #FOAvip English Wikipedia <ref>{{Cite pmid|27088599 }}</ref> Human Epithelial Cells Discriminate between Commensal and Pathogenic Interactions with Candida albicans #MMPMID27088599 Rast TJ ; Kullas AL ; Southern PJ ; Davis DA PLoS One 2016[]; 11 (4 ): e0153165 PMID27088599 show ga The commensal fungus, Candida albicans, can cause life-threatening infections in at risk individuals. C. albicans colonizes mucosal surfaces of most people, adhering to and interacting with epithelial cells. At low concentrations, C. albicans is not pathogenic nor does it cause epithelial cell damage in vitro; at high concentrations, C. albicans causes mucosal infections and kills epithelial cells in vitro. Here we show that while there are quantitative dose-dependent differences in exposed epithelial cell populations, these reflect a fundamental qualitative difference in host cell response to C. albicans. Using transcriptional profiling experiments and real time PCR, we found that wild-type C. albicans induce dose-dependent responses from a FaDu epithelial cell line. However, real time PCR and Western blot analysis using a high dose of various C. albicans strains demonstrated that these dose-dependent responses are associated with ability to promote host cell damage. Our studies support the idea that epithelial cells play a key role in the immune system by monitoring the microbial community at mucosal surfaces and initiating defensive responses when this community is dysfunctional. This places epithelial cells at a pivotal position in the interaction with C. albicans as epithelial cells themselves promote C. albicans stimulated damage. |*Host-Pathogen Interactions/genetics [MESH] |Candida albicans/genetics/*pathogenicity/physiology [MESH] |Cell Line [MESH] |DNA-Binding Proteins/genetics [MESH] |Enzyme Activation [MESH] |Epithelial Cells/*microbiology [MESH] |Fungal Proteins/genetics [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Inflammation/genetics [MESH] |Mitogen-Activated Protein Kinases/metabolism [MESH]Human Epithelial Cells Discriminate between Commensal and Pathogenic I(epmc).pdf DeepDyve Pubget Overpricing