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10.1021/acs.jmedchem.5b00686 http://scihub22266oqcxt.onion/10.1021/acs.jmedchem.5b00686 C4834983!4834983!26331426     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26331426.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Med+Chem 2015 ; 58 (19): 7734-48 Nephropedia Template TP {{tp|p=26331426|t=2015. Hirsutinolide series inhibit Stat3 activity, alter GCN1, MAP1B, Hsp105, G6PD, vimentin, TrxR1, and importin ?-2 expression, and induce antitumor effects against human glioma |pdf=|usr=}}{{26331426}} gab.com Text Hirsutinolide series inhibit Stat3 activity, alter GCN1, MAP1B, Hsp105, G6PD, vimentin, TrxR1, and importin -2 expression, and induce antitumor effects against human glioma JO: J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26331426 #FOAvip We report that hirsutinolides series, 6, 7, 10, 11, 20 and 22 and the semi-synthetic analogs, 30, 31, 33 and 36 inhibit constitutively-active Signal transducer and activator of transcription (Stat)3 and malignant glioma phenotype. A position 13 lipophilic ester group is required for activity. Molecular modeling and NMR structural analyses reveal direct hirsutinolide:Stat3 binding. One-hour treatment of cells with 6 and 22 also upregulated importin subunit ?-2 levels and repressed translational activator GCN1, microtubule-associated protein (MAP)1B, thioredoxin reductase (TrxR)1 cytoplasmic isoform 3, glucose-6-phosphate 1-dehydrogenase isoform a, Hsp105, vimentin, and tumor necrosis factor ?-induced protein (TNAP)2 expression. Active hirsutinolides inhibited anchorage-dependent and 3D-spheroid growth, survival, and migration of human glioma lines and glioma patients? tumor-derived xenograft cells harboring constitutively-active Stat3. Oral gavage delivery of 6 or 22 inhibited human glioma tumor growth in subcutaneous mouse xenografts. The inhibition of Stat3 signaling represents part of the hirsutinolide-mediated mechanisms to induce antitumor effects. Twit Text FOAVip Hirsutinolide series inhibit Stat3 activity, alter GCN1, MAP1B, Hsp105, G6PD, vimentin, TrxR1, and importin -2 expression, and induce antitumor effects against human glioma ????J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26331426 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26331426 #FOAvip English Wikipedia <ref>{{Cite pmid|26331426}}</ref> Hirsutinolide series inhibit Stat3 activity, alter GCN1, MAP1B, Hsp105, G6PD, vimentin, TrxR1, and importin ?-2 expression, and induce antitumor effects against human glioma #MMPMID26331426 Miklossy G; Youn UJ; Yue P; Zhang M; Chen CH; Hilliard TS; Paladino D; Li Y; Choi J; Sarkaria JN; Kawakami JK; Wongwiwatthananukit S; Chen Y; Sun D; Chang LC; Turkson J J Med Chem 2015[Oct]; 58 (19): 7734-48 PMID26331426show ga We report that hirsutinolides series, 6, 7, 10, 11, 20 and 22 and the semi-synthetic analogs, 30, 31, 33 and 36 inhibit constitutively-active Signal transducer and activator of transcription (Stat)3 and malignant glioma phenotype. A position 13 lipophilic ester group is required for activity. Molecular modeling and NMR structural analyses reveal direct hirsutinolide:Stat3 binding. One-hour treatment of cells with 6 and 22 also upregulated importin subunit ?-2 levels and repressed translational activator GCN1, microtubule-associated protein (MAP)1B, thioredoxin reductase (TrxR)1 cytoplasmic isoform 3, glucose-6-phosphate 1-dehydrogenase isoform a, Hsp105, vimentin, and tumor necrosis factor ?-induced protein (TNAP)2 expression. Active hirsutinolides inhibited anchorage-dependent and 3D-spheroid growth, survival, and migration of human glioma lines and glioma patients? tumor-derived xenograft cells harboring constitutively-active Stat3. Oral gavage delivery of 6 or 22 inhibited human glioma tumor growth in subcutaneous mouse xenografts. The inhibition of Stat3 signaling represents part of the hirsutinolide-mediated mechanisms to induce antitumor effects. äHirsutinolide series inhibit Stat3 activity, alter GCN1, MAP1B, Hsp105(epmc).pdf DeepDyve Pubget Overpricing