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10.1002/hep.28417 http://scihub22266oqcxt.onion/10.1002/hep.28417 C4834727!4834727!26698646     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26698646.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hepatology 2016 ; 63 (4): 1256-71 Nephropedia Template TP {{tp|p=26698646|t=2016. Actin?like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial?mesenchymal transition |pdf=|usr=}}{{26698646}} gab.com Text Actin like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial mesenchymal transition JO: Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=26698646 #FOAvip Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide because of metastasis. Epithelial?mesenchymal transition (EMT) is widely considered to be crucial to the invasion?metastasis cascade during cancer progression. Actin?like 6A (ACTL6A) is initially verified important for cell proliferation, differentiation, and migration. In this study, we find that ACTL6A plays an essential role in metastasis and EMT of HCC. ACTL6A expression is up?regulated in HCC cells and tissues. A high level of ACTL6A in HCCs is correlated with aggressive clinicopathological features and is an independent poor prognostic factor for overall and disease?free survival of HCC patients. Ectopic expression of ACTL6A markedly promotes HCC cells migration, invasion, as well as EMT in vitro and promotes tumor growth and metastasis in the mouse xenograft model. Opposite results are observed when ACTL6A is knocked down. Mechanistically, ACTL6A promotes metastasis and EMT through activating Notch signaling. ACTL6A knockdown has the equal blockage effect as the Notch signaling inhibitor, N?[N?(3,5?difluorophenacetyl)?L?alanyl]?S?phenylglycine t?butylester, in HCC cells. Further studies indicate that ACTL6A might manipulate SRY (sex determining region Y)?box 2 (SOX2) expression and then activate Notch1 signaling. Conclusions: ACTL6A promotes metastasis and EMT by SOX2/Notch1 signaling, indicating a prognostic biomarker candidate and a potential therapeutic target for HCC. (Hepatology 2016;63:1256?1271) Twit Text FOAVip Actin like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial mesenchymal transition ????Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=26698646 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26698646 #FOAvip English Wikipedia <ref>{{Cite pmid|26698646}}</ref> Actin?like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial?mesenchymal transition #MMPMID26698646 Xiao S; Chang R; Yang M; Lei X; Liu X; Gao W; Xiao J; Yang L Hepatology 2016[Apr]; 63 (4): 1256-71 PMID26698646show ga Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide because of metastasis. Epithelial?mesenchymal transition (EMT) is widely considered to be crucial to the invasion?metastasis cascade during cancer progression. Actin?like 6A (ACTL6A) is initially verified important for cell proliferation, differentiation, and migration. In this study, we find that ACTL6A plays an essential role in metastasis and EMT of HCC. ACTL6A expression is up?regulated in HCC cells and tissues. A high level of ACTL6A in HCCs is correlated with aggressive clinicopathological features and is an independent poor prognostic factor for overall and disease?free survival of HCC patients. Ectopic expression of ACTL6A markedly promotes HCC cells migration, invasion, as well as EMT in vitro and promotes tumor growth and metastasis in the mouse xenograft model. Opposite results are observed when ACTL6A is knocked down. Mechanistically, ACTL6A promotes metastasis and EMT through activating Notch signaling. ACTL6A knockdown has the equal blockage effect as the Notch signaling inhibitor, N?[N?(3,5?difluorophenacetyl)?L?alanyl]?S?phenylglycine t?butylester, in HCC cells. Further studies indicate that ACTL6A might manipulate SRY (sex determining region Y)?box 2 (SOX2) expression and then activate Notch1 signaling. Conclusions: ACTL6A promotes metastasis and EMT by SOX2/Notch1 signaling, indicating a prognostic biomarker candidate and a potential therapeutic target for HCC. (Hepatology 2016;63:1256?1271) äActin?like 6A predicts poor prognosis of hepatocellular carcinoma and (epmc).pdf DeepDyve Pubget Overpricing