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10.1038/ncomms11220 http://scihub22266oqcxt.onion/10.1038/ncomms11220 C4834629!4834629!27075392     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27075392|t=2016. Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms |pdf=|usr=}}{{27075392}} gab.com Text Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27075392 #FOAvip Many bacteria produce extracellular and surface-associated components such as membrane vesicles (MVs), extracellular DNA and moonlighting cytosolic proteins for which the biogenesis and export pathways are not fully understood. Here we show that the explosive cell lysis of a sub-population of cells accounts for the liberation of cytosolic content in Pseudomonas aeruginosa biofilms. Super-resolution microscopy reveals that explosive cell lysis also produces shattered membrane fragments that rapidly form MVs. A prophage endolysin encoded within the R- and F-pyocin gene cluster is essential for explosive cell lysis. Endolysin-deficient mutants are defective in MV production and biofilm development, consistent with a crucial role in the biogenesis of MVs and liberation of extracellular DNA and other biofilm matrix components. Our findings reveal that explosive cell lysis, mediated through the activity of a cryptic prophage endolysin, acts as a mechanism for the production of bacterial MVs. Twit Text FOAVip Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27075392 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27075392 #FOAvip English Wikipedia <ref>{{Cite pmid|27075392}}</ref> Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms #MMPMID27075392 Turnbull L; Toyofuku M; Hynen AL; Kurosawa M; Pessi G; Petty NK; Osvath SR; Cárcamo-Oyarce G; Gloag ES; Shimoni R; Omasits U; Ito S; Yap X; Monahan LG; Cavaliere R; Ahrens CH; Charles IG; Nomura N; Eberl L; Whitchurch CB Nat Commun 2016[]; 7 (ä): ä PMID27075392show ga Many bacteria produce extracellular and surface-associated components such as membrane vesicles (MVs), extracellular DNA and moonlighting cytosolic proteins for which the biogenesis and export pathways are not fully understood. Here we show that the explosive cell lysis of a sub-population of cells accounts for the liberation of cytosolic content in Pseudomonas aeruginosa biofilms. Super-resolution microscopy reveals that explosive cell lysis also produces shattered membrane fragments that rapidly form MVs. A prophage endolysin encoded within the R- and F-pyocin gene cluster is essential for explosive cell lysis. Endolysin-deficient mutants are defective in MV production and biofilm development, consistent with a crucial role in the biogenesis of MVs and liberation of extracellular DNA and other biofilm matrix components. Our findings reveal that explosive cell lysis, mediated through the activity of a cryptic prophage endolysin, acts as a mechanism for the production of bacterial MVs. äExplosive cell lysis as a mechanism for the biogenesis of bacterial me(epmc).pdf DeepDyve Pubget Overpricing