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2015 ; 128
(6
): 826-34
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English Wikipedia
Transjugular intrahepatic portosystemic shunt versus surgical shunting in the
management of portal hypertension
#MMPMID25758281
Huang L
; Yu QS
; Zhang Q
; Liu JD
; Wang Z
Chin Med J (Engl)
2015[Mar]; 128
(6
): 826-34
PMID25758281
show ga
BACKGROUND: The purpose of this article was to clarify the optimal management
concerning transjugular intrahepatic portosystemic shunts (TIPSs) and surgical
shunting in treating portal hypertension. METHODS: All databases, including CBM,
CNKI, WFPD, Medline, EMBASE, PubMed and Cochrane up to February 2014, were
searched for randomized controlled trials (RCTs) comparing TIPS with surgical
shunting. Four RCTs, which were extracted by two independent investigators and
were evaluated in postoperative complications, mortality, 2- and 5-year survival,
hospital stay, operating time and hospitalization charges. RESULTS: The morbidity
in variceal rehemorrhage was significantly higher in TIPS than in surgical shunts
(odds ratio [OR] = 7.45, 95% confidence interval[CI]: (3.93-14.15), P < 0.00001),
the same outcomes were seen in shunt stenosis (OR = 20.01, 95% CI: (6.67-59.99),
P < 0.000001) and in hepatic encephalopathy (OR = 2.50, 95% CI: (1.63-3.84), P <
0.0001). Significantly better 2-year survival (OR = 0.66; 95% CI: (0.44-0.98), P
= 0.04) and 5-year survival (OR = 0.44; 95% CI: (0.30-0.66), P < 0.00001) were
seen in patients undergoing surgical shunting compared with TIPS. CONCLUSIONS:
Compared with TIPS, postoperative complications and survival after surgical
shunting were superior for patients with portal hypertension. Application of
surgical shunting was recommended for patients rather than TIPS.