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10.2196/jmir.4541 http://scihub22266oqcxt.onion/10.2196/jmir.4541 C4833875!4833875 !27036325     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27036325 &cmd=llinks): Failed to open stream: HTTP request failed! 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Opportunities for Web-based Drug Repositioning: Searching for Potential Antihypertensive Agents with Hypotension Adverse Events |pdf=|usr=}}{{27036325 }} gab.com Text Opportunities for Web-based Drug Repositioning: Searching for Potential Antihypertensive Agents with Hypotension Adverse Events JO: J Med Internet Res http://www.kidney.de/pget.php?&tw=1&pmid=27036325 #FOAvip BACKGROUND: Drug repositioning refers to the process of developing new indications for existing drugs. As a phenotypic indicator of drug response in humans, clinical side effects may provide straightforward signals and unique opportunities for drug repositioning. OBJECTIVE: We aimed to identify drugs frequently associated with hypotension adverse reactions (ie, the opposite condition of hypertension), which could be potential candidates as antihypertensive agents. METHODS: We systematically searched the electronic records of the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) through the openFDA platform to assess the association between hypotension incidence and antihypertensive therapeutic effect regarding a list of 683 drugs. RESULTS: Statistical analysis of FAERS data demonstrated that those drugs frequently co-occurring with hypotension events were more likely to have antihypertensive activity. Ranked by the statistical significance of frequent hypotension reporting, the well-known antihypertensive drugs were effectively distinguished from others (with an area under the receiver operating characteristic curve > 0.80 and a normalized discounted cumulative gain of 0.77). In addition, we found a series of antihypertensive agents (particularly drugs originally developed for treating nervous system diseases) among the drugs with top significant reporting, suggesting the good potential of Web-based and data-driven drug repositioning. CONCLUSIONS: We found several candidate agents among the hypotension-related drugs on our list that may be redirected for lowering blood pressure. More important, we showed that a pharmacovigilance system could alternatively be used to identify antihypertensive agents and sustainably create opportunities for drug repositioning. Twit Text FOAVip Opportunities for Web-based Drug Repositioning: Searching for Potential Antihypertensive Agents with Hypotension Adverse Events ????J Med Internet Res http://www.kidney.de/pget.php?&tw=1&pmid=27036325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27036325 #FOAvip English Wikipedia <ref>{{Cite pmid|27036325 }}</ref> Opportunities for Web-based Drug Repositioning: Searching for Potential Antihypertensive Agents with Hypotension Adverse Events #MMPMID27036325 Wang K ; Wan M ; Wang RS ; Weng Z J Med Internet Res 2016[Apr]; 18 (4 ): e76 PMID27036325 show ga BACKGROUND: Drug repositioning refers to the process of developing new indications for existing drugs. As a phenotypic indicator of drug response in humans, clinical side effects may provide straightforward signals and unique opportunities for drug repositioning. OBJECTIVE: We aimed to identify drugs frequently associated with hypotension adverse reactions (ie, the opposite condition of hypertension), which could be potential candidates as antihypertensive agents. METHODS: We systematically searched the electronic records of the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) through the openFDA platform to assess the association between hypotension incidence and antihypertensive therapeutic effect regarding a list of 683 drugs. RESULTS: Statistical analysis of FAERS data demonstrated that those drugs frequently co-occurring with hypotension events were more likely to have antihypertensive activity. Ranked by the statistical significance of frequent hypotension reporting, the well-known antihypertensive drugs were effectively distinguished from others (with an area under the receiver operating characteristic curve > 0.80 and a normalized discounted cumulative gain of 0.77). In addition, we found a series of antihypertensive agents (particularly drugs originally developed for treating nervous system diseases) among the drugs with top significant reporting, suggesting the good potential of Web-based and data-driven drug repositioning. CONCLUSIONS: We found several candidate agents among the hypotension-related drugs on our list that may be redirected for lowering blood pressure. More important, we showed that a pharmacovigilance system could alternatively be used to identify antihypertensive agents and sustainably create opportunities for drug repositioning. |*Antihypertensive Agents/pharmacology/therapeutic use [MESH] |*Drug Repositioning [MESH] |*Internet [MESH] |*Pharmacovigilance [MESH] |Adverse Drug Reaction Reporting Systems [MESH] |Drug-Related Side Effects and Adverse Reactions [MESH] |Humans [MESH] |Hypertension/drug therapy [MESH] |Hypotension/*chemically induced [MESH] |United States [MESH]Opportunities for Web-based Drug Repositioning: Searching for Potentia(epmc).pdf DeepDyve Pubget Overpricing