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10.1161/HYPERTENSIONAHA.115.07012 http://scihub22266oqcxt.onion/10.1161/HYPERTENSIONAHA.115.07012 C4833618!4833618!26928805     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hypertension 2016 ; 67 (5): 927-33 Nephropedia Template TP {{tp|p=26928805|t=2016. ON THE ORIGIN OF URINARY RENIN A TRANSLATIONAL APPROACH |pdf=|usr=}}{{26928805}} gab.com Text ON THE ORIGIN OF URINARY RENIN A TRANSLATIONAL APPROACH JO: Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=26928805 #FOAvip Urinary angiotensinogen excretion parallels albumin excretion, which is not the case for renin, while renin?s precursor, prorenin, is undetectable in urine. We hypothesized that renin and prorenin, given their smaller size, are filtered through the glomerulus in larger amounts than albumin and angiotensinogen, and that differences in excretion rate are due to a difference in reabsorption in the proximal tubule. To address this, we determined the glomerular sieving coefficient (GSC) of renin and prorenin, and measured urinary renin/prorenin 1) after inducing prorenin in Cyp1a1-Ren2 rats, and 2) in patients with Dent?s disease or Lowe syndrome, disorders characterized by defective proximal tubular reabsorption. GSCs followed molecular size (renin>prorenin>albumin). The induction of prorenin in rats resulted in a >300-fold increase in plasma prorenin and doubling of blood pressure, but did not lead to the appearance of prorenin in urine. It did cause parallel rises in urinary renin and albumin, which losartan but not hydralazine prevented. Defective proximal tubular reabsorption increased urinary renin and albumin 20-40-fold, and allowed prorenin detection in urine, at ?50% of its levels in plasma. Taken together, these data indicate that circulating renin and prorenin are filtered into urine in larger amounts than albumin. All 3 proteins are subsequently reabsorbed in the proximal tubule. For prorenin such reabsorption is ?100%. Minimal variation in tubular reabsorption (in the order of a few %) is sufficient to explain why urinary renin and albumin excretion do not correlate. Urinary renin does not reflect prorenin that is converted to renin in tubular fluid. Twit Text FOAVip ON THE ORIGIN OF URINARY RENIN A TRANSLATIONAL APPROACH ????Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=26928805 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26928805 #FOAvip English Wikipedia <ref>{{Cite pmid|26928805}}</ref> ON THE ORIGIN OF URINARY RENIN A TRANSLATIONAL APPROACH #MMPMID26928805 Roksnoer LC; Heijnen BF; Nakano D; Peti-Peterdi J; Walsh SB; Garrelds IM; van Gool JM; Zietse R; Struijker-Boudier HA; Hoorn EJ; Danser AJ Hypertension 2016[May]; 67 (5): 927-33 PMID26928805show ga Urinary angiotensinogen excretion parallels albumin excretion, which is not the case for renin, while renin?s precursor, prorenin, is undetectable in urine. We hypothesized that renin and prorenin, given their smaller size, are filtered through the glomerulus in larger amounts than albumin and angiotensinogen, and that differences in excretion rate are due to a difference in reabsorption in the proximal tubule. To address this, we determined the glomerular sieving coefficient (GSC) of renin and prorenin, and measured urinary renin/prorenin 1) after inducing prorenin in Cyp1a1-Ren2 rats, and 2) in patients with Dent?s disease or Lowe syndrome, disorders characterized by defective proximal tubular reabsorption. GSCs followed molecular size (renin>prorenin>albumin). The induction of prorenin in rats resulted in a >300-fold increase in plasma prorenin and doubling of blood pressure, but did not lead to the appearance of prorenin in urine. It did cause parallel rises in urinary renin and albumin, which losartan but not hydralazine prevented. Defective proximal tubular reabsorption increased urinary renin and albumin 20-40-fold, and allowed prorenin detection in urine, at ?50% of its levels in plasma. Taken together, these data indicate that circulating renin and prorenin are filtered into urine in larger amounts than albumin. All 3 proteins are subsequently reabsorbed in the proximal tubule. For prorenin such reabsorption is ?100%. Minimal variation in tubular reabsorption (in the order of a few %) is sufficient to explain why urinary renin and albumin excretion do not correlate. Urinary renin does not reflect prorenin that is converted to renin in tubular fluid. äON THE ORIGIN OF URINARY RENIN A TRANSLATIONAL APPROACH (epmc).pdf DeepDyve Pubget Overpricing