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10.1158/2159-8290.CD-16-0238

http://scihub22266oqcxt.onion/10.1158/2159-8290.CD-16-0238
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C4832981!4832981!27045016
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suck abstract from ncbi


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pmid27045016      Cancer+Discov 2016 ; 6 (4): 344-6
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  • Molecular mechanism of mutant CALR-mediated transformation #MMPMID27045016
  • Stanley RF; Steidl U
  • Cancer Discov 2016[Apr]; 6 (4): 344-6 PMID27045016show ga
  • Elf and colleagues employed an elegant series of functional and biochemical assays to investigate the molecular mechanism of mutant calreticulin (CALR)-driven cellular transformation in myeloproliferative neoplasms (MPN). Mutant CALR is sufficient to induce MPN in mouse transplantation experiments and transformation is dependent upon physical interaction mediated by the positive electrostatic charge of the mutant CALR C-terminal domain and the thrombopoietin receptor (MPL) (1).
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