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10.4014/jmb.1512.12017

http://scihub22266oqcxt.onion/10.4014/jmb.1512.12017
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suck abstract from ncbi


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pmid26809802
      J+Microbiol+Biotechnol 2016 ; 26 (3 ): 567-71
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  • A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift #MMPMID26809802
  • Kim HB ; Wang Y ; Sun X
  • J Microbiol Biotechnol 2016[Mar]; 26 (3 ): 567-71 PMID26809802 show ga
  • We investigated the increased risk of Clostridium difficile infection (CDI) caused by the combined use of antibiotics and an immunosuppressive drug in a mouse model. Our data showed that an approximate return to pretreatment conditions of gut microbiota occurred within days after cessation of the antibiotic treatment, whereas the recovery of gut microbiota was delayed with the combined treatment of antibiotics and dexamethasone, leading to an increased severity of CDI. An alteration of gut microbiota is a key player in CDI. Therefore, our data implied that immunosuppressive drugs can increase the risk of CDI through the delayed recovery of altered gut microbiota.
  • |Animals [MESH]
  • |Bacteria/classification/drug effects/genetics/isolation & purification [MESH]
  • |Clostridioides difficile/*drug effects/physiology [MESH]
  • |Clostridium Infections/*drug therapy/microbiology [MESH]
  • |Dexamethasone/*adverse effects/therapeutic use [MESH]
  • |Gastrointestinal Microbiome/*drug effects [MESH]
  • |Gastrointestinal Tract/drug effects/microbiology [MESH]
  • |Humans [MESH]
  • |Immunosuppressive Agents/*adverse effects/therapeutic use [MESH]
  • |Mice [MESH]


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