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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Microbiol+Biotechnol
2016 ; 26
(3
): 567-71
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A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium
difficile Infection in Association with a Gastrointestinal Microbial Shift
#MMPMID26809802
Kim HB
; Wang Y
; Sun X
J Microbiol Biotechnol
2016[Mar]; 26
(3
): 567-71
PMID26809802
show ga
We investigated the increased risk of Clostridium difficile infection (CDI)
caused by the combined use of antibiotics and an immunosuppressive drug in a
mouse model. Our data showed that an approximate return to pretreatment
conditions of gut microbiota occurred within days after cessation of the
antibiotic treatment, whereas the recovery of gut microbiota was delayed with the
combined treatment of antibiotics and dexamethasone, leading to an increased
severity of CDI. An alteration of gut microbiota is a key player in CDI.
Therefore, our data implied that immunosuppressive drugs can increase the risk of
CDI through the delayed recovery of altered gut microbiota.