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10.1016/j.cmet.2016.03.008 http://scihub22266oqcxt.onion/10.1016/j.cmet.2016.03.008 C4832577!4832577!27076078     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2016 ; 23 (4): 649-62 Nephropedia Template TP {{tp|p=27076078|t=2016. AMPK is essential to balance glycolysis and mitochondrial metabolism to control T-ALL cell stress and survival |pdf=|usr=}}{{27076078}} gab.com Text AMPK is essential to balance glycolysis and mitochondrial metabolism to control T-ALL cell stress and survival JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27076078 #FOAvip T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with Notch pathway mutations. While both normal activated and leukemic T cells can utilize aerobic glycolysis to support proliferation, it is unclear to what extent these cell populations are metabolically similar and if differences reveal T-ALL vulnerabilities. Here we show that aerobic glycolysis is surprisingly less active in T-ALL cells than proliferating normal T cells and T-ALL cells are metabolically distinct. Oncogenic Notch promoted glycolysis but also induced metabolic stress that activated 5? AMP activated kinase (AMPK). Unlike stimulated T cells, AMPK actively restrained aerobic glycolysis in T-ALL cells through inhibition of mTORC1 while promoting oxidative metabolism and mitochondrial Complex I activity. Importantly, AMPK-deficiency or inhibition of Complex I led to T-ALL cell death and reduced disease burden. Thus AMPK simultaneously inhibits anabolic growth signaling and is essential to promote mitochondrial pathways that mitigate metabolic stress and apoptosis in T-ALL. Twit Text FOAVip AMPK is essential to balance glycolysis and mitochondrial metabolism to control T-ALL cell stress and survival ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27076078 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27076078 #FOAvip English Wikipedia <ref>{{Cite pmid|27076078}}</ref> AMPK is essential to balance glycolysis and mitochondrial metabolism to control T-ALL cell stress and survival #MMPMID27076078 Kishton RJ; Barnes CE; Nichols AG; Cohen S; Gerriets VA; Siska PJ; Macintyre AN; Goraksha-Hicks P; de Cubas AA; Liu T; Warmoes MO; Abel ED; Yeoh AEJ; Gershon TR; Rathmell WK; Richards KL; Locasale JW; Rathmell JC Cell Metab 2016[Apr]; 23 (4): 649-62 PMID27076078show ga T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with Notch pathway mutations. While both normal activated and leukemic T cells can utilize aerobic glycolysis to support proliferation, it is unclear to what extent these cell populations are metabolically similar and if differences reveal T-ALL vulnerabilities. Here we show that aerobic glycolysis is surprisingly less active in T-ALL cells than proliferating normal T cells and T-ALL cells are metabolically distinct. Oncogenic Notch promoted glycolysis but also induced metabolic stress that activated 5? AMP activated kinase (AMPK). Unlike stimulated T cells, AMPK actively restrained aerobic glycolysis in T-ALL cells through inhibition of mTORC1 while promoting oxidative metabolism and mitochondrial Complex I activity. Importantly, AMPK-deficiency or inhibition of Complex I led to T-ALL cell death and reduced disease burden. Thus AMPK simultaneously inhibits anabolic growth signaling and is essential to promote mitochondrial pathways that mitigate metabolic stress and apoptosis in T-ALL. äAMPK is essential to balance glycolysis and mitochondrial metabolism t(epmc).pdf DeepDyve Pubget Overpricing