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10.1016/j.cmet.2016.03.007 http://scihub22266oqcxt.onion/10.1016/j.cmet.2016.03.007 C4832569!4832569 !27076076     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27076076 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome |pdf=|usr=}}{{27076076 }} gab.com Text The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27076076 #FOAvip Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear whether enhancing clock function can ameliorate metabolic disorders. In an unbiased chemical screen using fibroblasts expressing PER2::Luc, we identified Nobiletin (NOB), a natural polymethoxylated flavone, as a clock amplitude-enhancing small molecule. When administered to diet-induced obese (DIO) mice, NOB strongly counteracted metabolic syndrome and augmented energy expenditure and locomotor activity in a Clock gene-dependent manner. In db/db mutant mice, the clock is also required for the mitigating effects of NOB on metabolic disorders. In DIO mouse liver, NOB enhanced clock protein levels and elicited pronounced gene expression remodeling. We identified retinoid acid receptor-related orphan receptors as direct targets of NOB, revealing a pharmacological intervention that enhances circadian rhythms to combat metabolic disease via the circadian gene network. Twit Text FOAVip The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27076076 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27076076 #FOAvip English Wikipedia <ref>{{Cite pmid|27076076 }}</ref> The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome #MMPMID27076076 He B ; Nohara K ; Park N ; Park YS ; Guillory B ; Zhao Z ; Garcia JM ; Koike N ; Lee CC ; Takahashi JS ; Yoo SH ; Chen Z Cell Metab 2016[Apr]; 23 (4 ): 610-21 PMID27076076 show ga Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear whether enhancing clock function can ameliorate metabolic disorders. In an unbiased chemical screen using fibroblasts expressing PER2::Luc, we identified Nobiletin (NOB), a natural polymethoxylated flavone, as a clock amplitude-enhancing small molecule. When administered to diet-induced obese (DIO) mice, NOB strongly counteracted metabolic syndrome and augmented energy expenditure and locomotor activity in a Clock gene-dependent manner. In db/db mutant mice, the clock is also required for the mitigating effects of NOB on metabolic disorders. In DIO mouse liver, NOB enhanced clock protein levels and elicited pronounced gene expression remodeling. We identified retinoid acid receptor-related orphan receptors as direct targets of NOB, revealing a pharmacological intervention that enhances circadian rhythms to combat metabolic disease via the circadian gene network. |Animals [MESH] |Circadian Rhythm/*drug effects [MESH] |Flavones/pharmacology/*therapeutic use [MESH] |Gene Expression Regulation/drug effects [MESH] |Liver/drug effects/metabolism/pathology [MESH] |Male [MESH] |Metabolic Syndrome/genetics/metabolism/pathology/*prevention & control [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Obese [MESH]The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhan(epmc).pdf DeepDyve Pubget Overpricing