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10.1182/blood-2015-09-672428

http://scihub22266oqcxt.onion/10.1182/blood-2015-09-672428
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C4832510!4832510!26837700
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suck abstract from ncbi


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pmid26837700      Blood 2016 ; 127 (15): 1930-9
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  • Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells #MMPMID26837700
  • Schönle A; Hartl FA; Mentzel J; Nöltner T; Rauch KS; Prestipino A; Wohlfeil SA; Apostolova P; Hechinger AK; Melchinger W; Fehrenbach K; Guadamillas MC; Follo M; Prinz G; Ruess AK; Pfeifer D; Angel del Pozo M; Schmitt-Graeff A; Duyster J; Hippen KI; Blazar BR; Schachtrup K; Minguet S; Zeiser R
  • Blood 2016[Apr]; 127 (15): 1930-9 PMID26837700show ga
  • Cav-1?deficient T cells preferentially differentiate into Tregs, which translates into lower GVHD severity in mice.Reduced TCR:Lck clustering in Cav-1?deficient T cells is responsible for reduced TCR downstream signaling events promoting Treg differentiation.
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