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10.1182/blood-2015-09-672428 http://scihub22266oqcxt.onion/10.1182/blood-2015-09-672428 C4832510!4832510 !26837700     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26837700 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood 2016 ; 127 (15 ): 1930-9 Nephropedia Template TP {{tp|p=26837700 |t=2016. Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells |pdf=|usr=}}{{26837700 }} gab.com Text Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=26837700 #FOAvip Caveolin-1 (Cav-1) is a key organizer of membrane specializations and a scaffold protein that regulates signaling in multiple cell types. We found increased Cav-1 expression in human and murine T cells after allogeneic hematopoietic cell transplantation. Indeed, Cav-1(-/-)donor T cells caused less severe acute graft-versus-host disease (GVHD) and yielded higher numbers of regulatory T cells (Tregs) compared with controls. Depletion of Tregs from the graft abrogated this protective effect. Correspondingly, Treg frequencies increased when Cav-1(-/-)T cells were exposed to transforming growth factor-?/T-cell receptor (TCR)/CD28 activation or alloantigen stimulation in vitro compared with wild-type T cells. Mechanistically, we found that the phosphorylation of Cav-1 is dispensable for the control of T-cell fate by using a nonphosphorylatable Cav-1 (Y14F/Y14F) point-mutation variant. Moreover, the close proximity of lymphocyte-specific protein tyrosine kinase (Lck) to the TCR induced by TCR-activation was reduced in Cav-1(-/-)T cells. Therefore, less TCR/Lck clustering results in suboptimal activation of the downstream signaling events, which correlates with the preferential development into a Treg phenotype. Overall, we report a novel role for Cav-1 in TCR/Lck spatial distribution upon TCR triggering, which controls T-cell fate toward a regulatory phenotype. This alteration translated into a significant increase in the frequency of Tregs and reduced GVHD in vivo. Twit Text FOAVip Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=26837700 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26837700 #FOAvip English Wikipedia <ref>{{Cite pmid|26837700 }}</ref> Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells #MMPMID26837700 Schönle A ; Hartl FA ; Mentzel J ; Nöltner T ; Rauch KS ; Prestipino A ; Wohlfeil SA ; Apostolova P ; Hechinger AK ; Melchinger W ; Fehrenbach K ; Guadamillas MC ; Follo M ; Prinz G ; Ruess AK ; Pfeifer D ; del Pozo MA ; Schmitt-Graeff A ; Duyster J ; Hippen KI ; Blazar BR ; Schachtrup K ; Minguet S ; Zeiser R Blood 2016[Apr]; 127 (15 ): 1930-9 PMID26837700 show ga Caveolin-1 (Cav-1) is a key organizer of membrane specializations and a scaffold protein that regulates signaling in multiple cell types. We found increased Cav-1 expression in human and murine T cells after allogeneic hematopoietic cell transplantation. Indeed, Cav-1(-/-)donor T cells caused less severe acute graft-versus-host disease (GVHD) and yielded higher numbers of regulatory T cells (Tregs) compared with controls. Depletion of Tregs from the graft abrogated this protective effect. Correspondingly, Treg frequencies increased when Cav-1(-/-)T cells were exposed to transforming growth factor-?/T-cell receptor (TCR)/CD28 activation or alloantigen stimulation in vitro compared with wild-type T cells. Mechanistically, we found that the phosphorylation of Cav-1 is dispensable for the control of T-cell fate by using a nonphosphorylatable Cav-1 (Y14F/Y14F) point-mutation variant. Moreover, the close proximity of lymphocyte-specific protein tyrosine kinase (Lck) to the TCR induced by TCR-activation was reduced in Cav-1(-/-)T cells. Therefore, less TCR/Lck clustering results in suboptimal activation of the downstream signaling events, which correlates with the preferential development into a Treg phenotype. Overall, we report a novel role for Cav-1 in TCR/Lck spatial distribution upon TCR triggering, which controls T-cell fate toward a regulatory phenotype. This alteration translated into a significant increase in the frequency of Tregs and reduced GVHD in vivo. |*Gene Expression Regulation [MESH] |Adaptor Proteins, Signal Transducing/genetics [MESH] |Animals [MESH] |CD28 Antigens/metabolism [MESH] |CD4-Positive T-Lymphocytes/cytology [MESH] |Caveolin 1/genetics/*metabolism/*physiology [MESH] |Cell Differentiation [MESH] |Forkhead Transcription Factors/metabolism [MESH] |Graft vs Host Disease/immunology [MESH] |Hematopoietic Stem Cell Transplantation [MESH] |Humans [MESH] |Lymphocyte Activation/immunology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Phosphorylation [MESH] |Prospective Studies [MESH] |Receptors, Antigen, T-Cell/*metabolism [MESH] |Signal Transduction [MESH] |T-Lymphocytes, Regulatory/cytology [MESH] |T-Lymphocytes/*cytology [MESH] |Transforming Growth Factor beta/metabolism [MESH]Caveolin-1 regulates TCR signal strength and regulatory T-cell differe(epmc).pdf DeepDyve Pubget Overpricing