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10.1002/path.4659 http://scihub22266oqcxt.onion/10.1002/path.4659 C4832394!4832394 !26467985     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26467985 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology |pdf=|usr=}}{{26467985 }} gab.com Text Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology JO: J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26467985 #FOAvip Obesity and diabetes represent a significant and escalating worldwide health burden. These conditions are characterized by abnormal nutrient homeostasis. One such perturbation is altered metabolism of the sulphur-containing amino acid cysteine. Obesity is associated with elevated plasma cysteine, whereas diabetes is associated with reduced cysteine levels. One mechanism by which cysteine may act is through its enzymatic breakdown to produce hydrogen sulphide (H2S), a gasotransmitter that regulates glucose and lipid homeostasis. Here we review evidence from both pharmacological studies and transgenic models suggesting that cysteine and hydrogen sulphide play a role in the metabolic dysregulation underpinning obesity and diabetes. We then outline the growing evidence that regulation of hydrogen sulphide levels through its catabolism can impact metabolic health. By integrating hydrogen sulphide production and breakdown pathways, we re-assess current hypothetical models of cysteine and hydrogen sulphide metabolism, offering new insight into their roles in the pathogenesis of obesity and diabetes. Twit Text FOAVip Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology ????J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26467985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26467985 #FOAvip English Wikipedia <ref>{{Cite pmid|26467985 }}</ref> Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology #MMPMID26467985 Carter RN ; Morton NM J Pathol 2016[Jan]; 238 (2 ): 321-32 PMID26467985 show ga Obesity and diabetes represent a significant and escalating worldwide health burden. These conditions are characterized by abnormal nutrient homeostasis. One such perturbation is altered metabolism of the sulphur-containing amino acid cysteine. Obesity is associated with elevated plasma cysteine, whereas diabetes is associated with reduced cysteine levels. One mechanism by which cysteine may act is through its enzymatic breakdown to produce hydrogen sulphide (H2S), a gasotransmitter that regulates glucose and lipid homeostasis. Here we review evidence from both pharmacological studies and transgenic models suggesting that cysteine and hydrogen sulphide play a role in the metabolic dysregulation underpinning obesity and diabetes. We then outline the growing evidence that regulation of hydrogen sulphide levels through its catabolism can impact metabolic health. By integrating hydrogen sulphide production and breakdown pathways, we re-assess current hypothetical models of cysteine and hydrogen sulphide metabolism, offering new insight into their roles in the pathogenesis of obesity and diabetes. |*Disease Models, Animal [MESH] |*Models, Genetic [MESH] |Adipose Tissue/metabolism [MESH] |Animals [MESH] |Blood Glucose/metabolism [MESH] |Cysteine/*metabolism [MESH] |Diabetes Mellitus, Type 2/genetics/*metabolism [MESH] |Hydrogen Sulfide/*metabolism [MESH] |Insulin Secretion [MESH] |Insulin-Secreting Cells/metabolism [MESH] |Insulin/metabolism [MESH] |Lipid Metabolism/physiology [MESH] |Lipid Peroxidation/physiology [MESH] |Liver/metabolism [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Obesity/genetics/*metabolism [MESH]Cysteine and hydrogen sulphide in the regulation of metabolism: insigh(epmc).pdf DeepDyve Pubget Overpricing