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10.1002/eji.201545995 http://scihub22266oqcxt.onion/10.1002/eji.201545995 C4832341!4832341 !26694097     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26694097 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Immunol 2016 ; 46 (4 ): 846-56 Nephropedia Template TP {{tp|p=26694097 |t=2016. Dynamic spatio-temporal contribution of single ?5t+ cortical epithelial precursors to the thymus medulla |pdf=|usr=}}{{26694097 }} gab.com Text Dynamic spatio-temporal contribution of single 5t+ cortical epithelial precursors to the thymus medulla JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26694097 #FOAvip Intrathymic T-cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit ?5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that ?5t(+) TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has completely formed. Lineage-tracing studies at single cell resolution demonstrate for young mice that the postnatal medulla is expanded from individual ?5t(+) cortical progenitors located at the cortico-medullary junction. These results therefore not only define a developmental window during which the expansion of medulla is efficiently enabled by progenitors resident in the thymic cortex, but also reveal the spatio-temporal dynamics that control the growth of the thymic medulla. Twit Text FOAVip Dynamic spatio-temporal contribution of single 5t+ cortical epithelial precursors to the thymus medulla ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26694097 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26694097 #FOAvip English Wikipedia <ref>{{Cite pmid|26694097 }}</ref> Dynamic spatio-temporal contribution of single ?5t+ cortical epithelial precursors to the thymus medulla #MMPMID26694097 Mayer CE ; ?uklys S ; Zhanybekova S ; Ohigashi I ; Teh HY ; Sansom SN ; Shikama-Dorn N ; Hafen K ; Macaulay IC ; Deadman ME ; Ponting CP ; Takahama Y ; Holländer GA Eur J Immunol 2016[Apr]; 46 (4 ): 846-56 PMID26694097 show ga Intrathymic T-cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit ?5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that ?5t(+) TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has completely formed. Lineage-tracing studies at single cell resolution demonstrate for young mice that the postnatal medulla is expanded from individual ?5t(+) cortical progenitors located at the cortico-medullary junction. These results therefore not only define a developmental window during which the expansion of medulla is efficiently enabled by progenitors resident in the thymic cortex, but also reveal the spatio-temporal dynamics that control the growth of the thymic medulla. |Animals [MESH] |Cell Differentiation [MESH] |Cell Lineage/immunology [MESH] |Cell Proliferation [MESH] |Doxycycline/pharmacology [MESH] |Epithelial Cells/*cytology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Organogenesis/physiology [MESH] |Proteasome Endopeptidase Complex/*metabolism [MESH] |Stem Cells/cytology [MESH] |T-Lymphocytes/*cytology/immunology [MESH]Dynamic spatio-temporal contribution of single ?5t+ cortical epithelia(epmc).pdf DeepDyve Pubget Overpricing